[4] Atlas 2-1 Santos Laguna [17] 2022-02-07 00:00
Stadium: Estadio Jalisco Round: 4
Referee: Jorge Antonio Perez Duran Home Manager: Diego Cocca Away Manager: Pedro Caixinha
Head to Head
| Mexico Liga MX | 2021/08/19 00:00 | Santos Laguna v Atlas | D | 1-1 |
| Mexico Liga MX | 2021/02/06 23:00 | Atlas v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2020/08/17 00:06 | Santos Laguna v Atlas | D | 0-0 |
| Mexico Liga MX | 2020/03/02 00:45 | Santos Laguna v Atlas | L | 1-0 |
| Mexico Liga MX | 2019/08/03 02:00 | Atlas v Santos Laguna | L | 1-2 |
| Mexico Liga MX | 2019/03/30 03:00 | Atlas v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2018/10/06 00:00 | Santos Laguna v Atlas | L | 3-1 |
| Mexico Liga MX | 2018/03/31 03:00 | Atlas v Santos Laguna | W | 3-2 |
| Mexico Liga MX | 2017/10/15 23:30 | Santos Laguna v Atlas | W | 0-1 |
| Mexico Liga MX | 2017/04/16 00:00 | Atlas v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2016/10/23 23:00 | Santos Laguna v Atlas | D | 2-2 |
| Mexico Liga MX | 2016/03/06 02:30 | Atlas v Santos Laguna | L | 1-2 |
| Mexico Liga MX | 2015/09/19 02:30 | Santos Laguna v Atlas | W | 0-2 |
| Mexico Liga MX | 2015/02/21 03:30 | Santos Laguna v Atlas | W | 0-1 |
| Mexico Liga MX | 2014/08/31 02:00 | Atlas v Santos Laguna | D | 1-1 |