[9] Guairena FC 0-0 Guarani Asuncion [8] 2022-02-06 21:15
Stadium: Estadio Parque del Guaira Round: 1
Referee: Jose Mendez Home Manager: Troadio Daniel Duarte Away Manager: Fernando Jubero Carmona
Head to Head
| Paraguay Division Profesional | 2021/11/28 22:00 | Guairena FC v Guarani Asuncion | D | 1-1 |
| Paraguay Division Profesional | 2021/09/12 00:15 | Guarani Asuncion v Guairena FC | L | 3-0 |
| Paraguay Division Profesional | 2021/05/21 23:00 | Guairena FC v Guarani Asuncion | D | 0-0 |
| Paraguay Division Profesional | 2021/03/14 20:45 | Guarani Asuncion v Guairena FC | W | 0-3 |
| Paraguay Division Profesional | 2020/12/28 00:00 | Guairena FC v Guarani Asuncion | L | 0-1 |
| Paraguay Division Profesional | 2020/12/19 22:30 | Guarani Asuncion v Guairena FC | L | 1-0 |
| Paraguay Division Profesional | 2020/09/20 21:00 | Guarani Asuncion v Guairena FC | D | 0-0 |
| Paraguay Division Profesional | 2020/07/23 22:00 | Guairena FC v Guarani Asuncion | D | 1-1 |