2 de Mayo 1-2 River Plate Asuncion 2022-04-18 19:00
Stadium: Estadio Monumental Rio Parapiti Round: 3
Head to Head
| Paraguay Division Intermedia | 2018/09/02 19:00 | 2 de Mayo v River Plate Asuncion | W | 3-1 |
| Paraguay Division Intermedia | 2018/05/26 19:00 | River Plate Asuncion v 2 de Mayo | L | 2-0 |