[21] Colchester 2-2 Leyton Orient [18] 2022-03-01 19:45
Stadium: JobServe Community Stadium Round: 23
Referee: Neil Hair Home Manager: Wayne Brown Away Manager: Kenneth Francis Jackett
Head to Head
| England League 2 | 2022/02/05 15:00 | Leyton Orient v Colchester | W | 0-1 |
| England League 2 | 2021/02/06 15:00 | Leyton Orient v Colchester | D | 0-0 |
| England League 2 | 2020/11/14 15:00 | Colchester v Leyton Orient | W | 2-1 |
| England League 2 | 2019/12/26 13:00 | Leyton Orient v Colchester | W | 1-3 |
| England League 2 | 2019/09/21 14:00 | Colchester v Leyton Orient | W | 2-1 |
| England League 2 | 2017/04/29 14:00 | Leyton Orient v Colchester | W | 1-3 |
| England League 2 | 2016/11/12 15:00 | Colchester v Leyton Orient | L | 0-3 |
| Club Friendly List | 2015/07/25 14:00 | Colchester v Leyton Orient | L | 0-3 |
| England League 1 | 2015/01/24 15:00 | Colchester v Leyton Orient | W | 2-0 |
| England League 1 | 2014/09/13 14:00 | Leyton Orient v Colchester | W | 0-2 |