[17] Club Deportes Santa Cruz 2-0 San Luis Quillota [12] 2022-05-18 00:30
Stadium: Estadio Municipal Joaquín Muñoz García Round: 15
Head to Head
| Chile Primera B | 2021/10/12 21:00 | San Luis Quillota v Club Deportes Santa Cruz | D | 0-0 |
| Chile Primera B | 2021/07/11 19:30 | Club Deportes Santa Cruz v San Luis Quillota | W | 2-0 |
| Chile Primera B | 2020/12/30 21:15 | Club Deportes Santa Cruz v San Luis Quillota | L | 1-3 |
| Chile Primera B | 2020/09/23 19:00 | San Luis Quillota v Club Deportes Santa Cruz | D | 0-0 |
| Chile Primera B | 2019/08/19 23:30 | Club Deportes Santa Cruz v San Luis Quillota | L | 2-3 |
| Chile Primera B | 2019/05/11 23:00 | San Luis Quillota v Club Deportes Santa Cruz | L | 2-1 |