[8] Club Deportes Santa Cruz 1-1 Cobreloa [2] 2022-08-01 00:30
Stadium: Estadio Municipal Joaquín Muñoz García Round: 22
Head to Head
| Chile Primera B | 2022/06/02 19:00 | Cobreloa v Club Deportes Santa Cruz | L | 1-0 |
| Chile Primera B | 2021/11/06 23:30 | Club Deportes Santa Cruz v Cobreloa | D | 2-2 |
| Chile Primera B | 2021/08/08 15:00 | Cobreloa v Club Deportes Santa Cruz | W | 0-1 |
| Chile Primera B | 2020/12/10 13:00 | Club Deportes Santa Cruz v Cobreloa | W | 4-1 |
| Chile Primera B | 2020/09/06 15:00 | Cobreloa v Club Deportes Santa Cruz | W | 0-1 |
| Chile Primera B | 2019/06/02 19:00 | Club Deportes Santa Cruz v Cobreloa | W | 1-0 |