[4] Coban Imperial 5-1 Nueva Concepcion [11] 2022-04-09 21:00
Stadium: Estadio Jose Angel Rossi Round: 16
Head to Head
| Guatemala Liga Nacional | 2022/02/05 18:00 | Nueva Concepcion v Coban Imperial | W | 1-2 |
| Guatemala Liga Nacional | 2021/10/17 16:00 | Coban Imperial v Nueva Concepcion | W | 2-0 |
| Guatemala Liga Nacional | 2021/08/18 17:00 | Nueva Concepcion v Coban Imperial | L | 2-1 |