[8] Guairena FC 1-1 Nacional Asuncion [6] 2022-07-01 21:00
Stadium: Estadio Parque del Guaira Round: 22
Referee: Samuel Morales Home Manager: Troadio Daniel Duarte Away Manager: Pedro Sarabia
Head to Head
| Paraguay Division Profesional | 2022/04/20 22:00 | Nacional Asuncion v Guairena FC | L | 3-1 |
| Copa Sudamericana | 2022/03/17 22:15 | Guairena FC v Nacional Asuncion | D | 0-0 |
| Copa Sudamericana | 2022/03/10 22:15 | Nacional Asuncion v Guairena FC | W | 0-1 |
| Paraguay Division Profesional | 2021/11/08 23:30 | Guairena FC v Nacional Asuncion | D | 0-0 |
| Paraguay Division Profesional | 2021/08/20 23:30 | Nacional Asuncion v Guairena FC | W | 0-2 |
| Paraguay Division Profesional | 2021/04/30 22:00 | Nacional Asuncion v Guairena FC | W | 1-3 |
| Paraguay Division Profesional | 2021/03/01 21:30 | Guairena FC v Nacional Asuncion | W | 1-0 |
| Paraguay Division Profesional | 2020/11/22 21:30 | Nacional Asuncion v Guairena FC | D | 0-0 |
| Paraguay Division Profesional | 2020/08/07 20:00 | Guairena FC v Nacional Asuncion | D | 0-0 |
| Paraguay Division Profesional | 2020/01/18 21:00 | Nacional Asuncion v Guairena FC | L | 3-0 |