[5] FC Cincinnati 2-3 Chicago Fire [12] 2022-10-01 23:30
Stadium: TQL Stadium
Referee: Lukasz Szpala Home Manager: Pat Noonan Away Manager: Ezra Hendrickson
Head to Head
| USA MLS | 2022/05/15 00:00 | Chicago Fire v FC Cincinnati | W | 1-2 |
| USA MLS | 2021/10/20 23:30 | FC Cincinnati v Chicago Fire | L | 3-4 |
| USA MLS | 2021/06/24 00:00 | Chicago Fire v FC Cincinnati | W | 0-1 |
| USA MLS | 2020/09/02 23:30 | FC Cincinnati v Chicago Fire | D | 0-0 |
| USA MLS | 2020/08/25 23:30 | Chicago Fire v FC Cincinnati | L | 3-0 |
| USA MLS | 2019/09/21 23:30 | FC Cincinnati v Chicago Fire | D | 0-0 |
| USA MLS | 2019/07/14 00:00 | Chicago Fire v FC Cincinnati | W | 1-2 |
| World Club Friendlies | 2019/02/21 00:30 | FC Cincinnati v Chicago Fire | D | 1-1 |
| USA US Open Cup | 2017/06/29 00:00 | FC Cincinnati v Chicago Fire | W | 3-1 |
| Club Friendly List | 2017/02/22 21:00 | Chicago Fire v FC Cincinnati | L | 3-2 |