[3] Guaynabo 104-122 Gigantes Carolina [6] 2022-05-13 00:00
Stadium: Mario Morales Coliseum Round: 1
Head to Head
| Puerto Rico Superior Nacional | 2021/09/08 00:00 | Gigantes Carolina v Guaynabo | L | 92-86 |
| Puerto Rico Superior Nacional | 2021/08/29 00:00 | Guaynabo v Gigantes Carolina | W | 107-96 |
| Puerto Rico Superior Nacional | 2021/08/01 00:00 | Guaynabo v Gigantes Carolina | W | 119-102 |
| Puerto Rico Superior Nacional | 2021/07/24 00:00 | Gigantes Carolina v Guaynabo | L | 82-75 |