[7] Real Santa Cruz 2-1 Oriente Petrolero [4] 2022-04-02 19:00
Stadium: Estadio Juan Carlos Duran Round: 7
Head to Head
| Bolivia Apertura | 2021/12/05 00:30 | Oriente Petrolero v Real Santa Cruz | L | 2-0 |
| Bolivia Apertura | 2021/08/07 19:00 | Real Santa Cruz v Oriente Petrolero | D | 0-0 |
| Bolivia Apertura | 2020/12/16 23:30 | Oriente Petrolero v Real Santa Cruz | L | 3-2 |
| Bolivia Apertura | 2020/02/16 19:00 | Real Santa Cruz v Oriente Petrolero | L | 1-5 |