[4] Penarol 1-0 Boston River [5] 2022-05-21 22:30
Stadium: Estadio Campeon del Siglo Round: 13
Referee: Gustavo Tejera Home Manager: Mauricio Larriera Away Manager: Ignacio Ithurralde
Head to Head
| Uruguay Clausura | 2021/09/26 18:30 | Boston River v Penarol | W | 2-5 |
| Uruguay Apertura | 2021/05/30 21:00 | Penarol v Boston River | W | 5-2 |
| Uruguay Clausura | 2021/02/07 00:45 | Boston River v Penarol | W | 1-2 |
| Uruguay Torneo Intermedio | 2020/11/22 22:30 | Penarol v Boston River | W | 2-0 |
| Uruguay Apertura | 2020/08/16 20:30 | Penarol v Boston River | W | 2-0 |
| Uruguay Clausura | 2019/10/20 21:00 | Penarol v Boston River | W | 1-0 |
| Uruguay Torneo Intermedio | 2019/07/14 21:00 | Penarol v Boston River | W | 4-0 |
| Uruguay Apertura | 2019/03/30 22:00 | Boston River v Penarol | W | 0-4 |
| Uruguay Clausura | 2018/08/26 18:00 | Boston River v Penarol | W | 1-2 |
| Uruguay Torneo Intermedio | 2018/05/23 23:00 | Penarol v Boston River | W | 3-0 |
| Uruguay Apertura | 2018/03/10 19:30 | Penarol v Boston River | W | 2-1 |
| Uruguay Clausura | 2017/09/03 22:00 | Boston River v Penarol | W | 0-1 |
| Uruguay Torneo Intermedio | 2017/06/05 23:30 | Boston River v Penarol | D | 0-0 |
| Uruguay Apertura | 2017/02/19 23:00 | Penarol v Boston River | D | 0-0 |
| Uruguay Apertura | 2016/09/18 22:00 | Boston River v Penarol | D | 0-0 |