[15] SF 49ers 10-11 DEN Broncos [17] 2022-09-26 00:20
Stadium: Empower Field at Mile High Round: 1
Home Manager: Nathaniel Hackett Away Manager: Kyle Shanahan
Head to Head
| NFL Preseason | 2019/08/20 00:00 | SF 49ers v DEN Broncos | W | 24-15 |
| NFL | 2018/12/09 21:05 | DEN Broncos v SF 49ers | W | 14-20 |
| NFL Preseason | 2017/08/20 02:00 | DEN Broncos v SF 49ers | L | 33-14 |
| NFL Preseason | 2016/08/21 01:00 | DEN Broncos v SF 49ers | W | 24-31 |
| NFL | 2014/10/20 00:30 | DEN Broncos v SF 49ers | L | 42-17 |