Head to Head
| NFL Preseason | 2021/08/15 00:30 | KC Chiefs v SF 49ers | W | 19-16 |
| NFL | 2020/02/02 23:30 | SF 49ers v KC Chiefs | W | 20-31 |
| NFL Preseason | 2019/08/25 00:00 | SF 49ers v KC Chiefs | L | 27-17 |
| NFL | 2018/09/23 17:00 | SF 49ers v KC Chiefs | W | 27-38 |
| NFL Preseason | 2017/08/12 01:00 | SF 49ers v KC Chiefs | L | 27-17 |
| NFL | 2014/10/05 20:25 | SF 49ers v KC Chiefs | L | 22-17 |