[16] Tlaxcala FC 2-0 Universidad Guadalajara [4] 2022-09-01 00:05
Stadium: Estadio Tlahuicole Round: 10
Head to Head
| Mexico Liga de Expansion | 2022/03/20 16:00 | Tlaxcala FC v Universidad Guadalajara | L | 1-2 |
| Mexico Liga de Expansion | 2021/10/27 22:00 | Universidad Guadalajara v Tlaxcala FC | L | 1-0 |
| Mexico Liga de Expansion | 2021/01/17 23:00 | Universidad Guadalajara v Tlaxcala FC | D | 1-1 |
| Mexico Liga de Expansion | 2020/09/15 21:00 | Tlaxcala FC v Universidad Guadalajara | L | 1-3 |