[15] Tranmere 1-0 Leyton Orient [1] 2023-01-28 15:00
Stadium: Prenton Park Round: 29
Referee: Ollie Yates Home Manager: Micky Mellon Away Manager: Richie Wellens
Head to Head
| England League 2 | 2022/09/03 14:00 | Leyton Orient v Tranmere | L | 2-0 |
| England League 2 | 2022/05/07 14:00 | Leyton Orient v Tranmere | W | 0-1 |
| England League 2 | 2021/12/18 15:00 | Tranmere v Leyton Orient | W | 1-0 |
| England FA Cup | 2021/12/04 15:00 | Leyton Orient v Tranmere | L | 4-0 |
| England League 2 | 2021/02/27 15:00 | Leyton Orient v Tranmere | W | 1-3 |
| England League 2 | 2020/10/20 18:00 | Tranmere v Leyton Orient | L | 0-1 |
| England National League | 2018/02/10 15:00 | Leyton Orient v Tranmere | D | 1-1 |
| England National League | 2017/10/04 18:45 | Tranmere v Leyton Orient | W | 2-1 |