East Tennessee State 33-55 Mercer 2022-10-15 20:00
Stadium: Five Star Stadium Round: 1
Home Manager: Drew Cronic Away Manager: George Quarles
Head to Head
| NCAAF | 2021/11/20 18:00 | Mercer v East Tennessee State | W | 35-38 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | L | 13-21 |
| NCAAF | 2019/11/16 18:00 | Mercer v East Tennessee State | W | 33-38 |
| NCAAF FCS | 2018/11/03 19:00 | East Tennessee State v Mercer | W | 21-18 |
| NCAAF | 2017/09/23 19:30 | East Tennessee State v Mercer | W | 26-23 |