[6] Guairena FC 3-2 Resistencia FC [5] 2022-10-10 20:00
Stadium: Estadio Parque del Guaira Round: 16
Referee: Alipio Colman Home Manager: Troadio Daniel Duarte Away Manager: Roberto Ismael Torres
Head to Head
| Paraguay Division Profesional | 2022/08/05 21:00 | Resistencia FC v Guairena FC | W | 1-2 |
| Paraguay Division Profesional | 2022/05/14 20:00 | Guairena FC v Resistencia FC | D | 0-0 |
| Paraguay Division Profesional | 2022/03/05 21:00 | Resistencia FC v Guairena FC | D | 2-2 |
| Paraguay Division Intermedia | 2019/10/20 12:00 | Resistencia FC v Guairena FC | D | 2-2 |
| Paraguay Division Intermedia | 2019/07/07 19:00 | Guairena FC v Resistencia FC | W | 4-1 |
| Paraguay Division Intermedia | 2018/09/09 14:00 | Guairena FC v Resistencia FC | W | 3-0 |
| Paraguay Division Intermedia | 2018/06/02 19:00 | Resistencia FC v Guairena FC | D | 0-0 |
| Paraguay Division Intermedia | 2017/07/02 19:00 | Guairena FC v Resistencia FC | D | 2-2 |
| Paraguay Division Intermedia | 2017/03/26 19:30 | Resistencia FC v Guairena FC | L | 3-0 |