[10] Northampton 38-22 London Irish [1] 2022-09-17 13:00
Stadium: Franklin's Gardens Round: 2
Referee: Luke Pearce
Head to Head
| Premiership Rugby | 2022/03/26 15:00 | London Irish v Northampton | W | 22-42 |
| Premiership Rugby Cup | 2021/11/13 15:30 | Northampton v London Irish | L | 26-36 |
| Premiership Rugby | 2021/10/02 13:00 | Northampton v London Irish | W | 23-21 |
| Premiership Rugby | 2021/04/16 18:45 | Northampton v London Irish | W | 44-26 |
| Premiership Rugby | 2020/08/22 13:00 | London Irish v Northampton | W | 3-27 |
| Premiership Rugby | 2020/01/24 19:45 | Northampton v London Irish | L | 16-20 |
| Premiership Rugby | 2018/02/17 15:00 | Northampton v London Irish | W | 25-17 |
| Premiership Rugby | 2017/09/24 14:00 | London Irish v Northampton | W | 25-40 |
| Premiership Rugby | 2016/02/13 15:00 | Northampton v London Irish | W | 35-7 |
| Premiership Rugby | 2015/12/26 14:30 | London Irish v Northampton | L | 25-23 |
| Premiership Rugby | 2015/02/13 19:45 | Northampton v London Irish | W | 15-9 |
| Premiership Rugby | 2014/10/04 14:00 | London Irish v Northampton | W | 12-19 |