Head to Head
| NFL Preseason | 2024/08/10 17:00 | CHI Bears v BUF Bills | L | 33-6 |
| NFL Preseason | 2023/08/26 17:00 | BUF Bills v CHI Bears | W | 24-21 |
| NFL | 2022/12/24 18:00 | BUF Bills v CHI Bears | W | 35-13 |
| NFL Preseason | 2021/08/21 17:00 | BUF Bills v CHI Bears | W | 41-15 |
| NFL | 2018/11/04 18:00 | CHI Bears v BUF Bills | L | 41-9 |
| NFL Preseason | 2018/08/31 00:00 | BUF Bills v CHI Bears | W | 28-27 |
| NFL | 2014/09/07 17:00 | CHI Bears v BUF Bills | W | 20-23 |