Michigan State 35-21 Indiana 2018-09-22 23:30
Stadium: Memorial Stadium (Bloomington, IN) Round: 1
Home Manager: Tom Allen Away Manager: Mark Dantonio
Head to Head
| NCAAF | 2017/10/21 19:30 | Indiana v Michigan State | W | 9-17 |
| NCAAF | 2016/10/02 00:00 | Michigan State v Indiana | L | 21-24 |
| NCAAF | 2015/10/24 19:30 | Michigan State v Indiana | W | 52-26 |
| NCAAF | 2014/10/18 19:30 | Indiana v Michigan State | W | 17-56 |
| NCAAF | 2012/10/06 12:00 | Indiana v Michigan State | W | 27-31 |
| NCAAF | 2011/11/19 12:00 | Michigan State v Indiana | W | 55-3 |
| NCAAF | 2008/09/27 12:00 | Indiana v Michigan State | W | 29-42 |
| NCAAF | 2007/10/13 12:00 | Michigan State v Indiana | W | 52-27 |
| NCAAF | 2005/10/29 12:00 | Michigan State v Indiana | W | 46-15 |
| NCAAF | 2004/09/25 12:00 | Indiana v Michigan State | W | 20-30 |
| NCAAF | 2003/10/04 12:00 | Michigan State v Indiana | W | 31-3 |
| NCAAF | 2002/11/09 12:00 | Indiana v Michigan State | W | 21-56 |
| NCAAF | 2001/11/10 12:00 | Michigan State v Indiana | L | 28-37 |