Francisco Cerundolo

Cerúndolo made his ATP main draw debut on home soil at the 2019 Argentina Open in Buenos Aires after receiving a wildcard for the singles main draw, losing to Guido Pella in three sets.

Cerúndolo played another ATP main draw a year later at the 2020 Argentina Open in Buenos Aires after receiving a wildcard for the singles main draw again, losing to Laslo Djere in the first round.

In January 2021, he was one of two players to test positive for COVID-19 during the Australian Open qualifying event in Doha.

Cerúndolo reached his first ATP tour final at the 2021 Argentina Open as a qualifier but was defeated by world No. 9 Diego Schwartzman. He was the first qualifier to reach the final in Buenos Aires since José Acasuso in 2001. At the time, Acasuso was coached by Cerúndolo's father, Alejandro Cerúndolo.

Cerúndolo made his main draw debut in a Grand Slam at the 2021 French Open as a lucky loser, where he lost to Thiago Monteiro.

Cerúndolo qualified to represent Argentina at the 2020 Summer Olympics.

At the 2022 Argentina Open, he reached the quarterfinals of his home tournament as a qualifier defeating Miomir Kecmanović. As a result, he reached the top 100 in the singles rankings, joining Juan Manuel Cerúndolo as the first brothers in the Top 100 at the same time since Alexander Zverev and Mischa Zverev in May 2019. Cerúndolo received a special exempt into the tournament in Rio de Janeiro the following week. There, he beat Benoît Paire, Roberto Carballés Baena and again Kecmanović to reach his first ATP 500 semifinal, where he lost in straight sets to Diego Schwartzman.

Cerúndolo recorded his first ATP Tour victories on a hard court at the Masters 1000 event in Miami, defeating Tallon Griekspoor and seeded players Reilly Opelka and Gaël Monfils en route to the fourth round. He beat Frances Tiafoe (who defeated his brother Juan Manuel in the third round) in the fourth round to advance to the quarterfinals. He advanced to the semifinals after Jannik Sinner retired during their match due to foot blisters. Ranked World No. 103 at the time, he became the lowest-ranked semifinalist in the history of the Miami Open, and also became the first male player since Jerzy Janowicz in 2012 to reach the semifinals on their Masters 1000 level debut. He lost to 6th seed Casper Ruud in the semifinals in straight sets. Following this result, his ranking rose 52 places to a career-high of World No. 51.

In Båstad, Cerúndolo recorded his first win against a player inside the Top-10 after beating top seed and defending champion Casper Ruud in 3 sets. He proceeded to reach the final after beating Aslan Karatsev and Pablo Carreño Busta. He defeated Sebastián Báez in the final to win his first ATP title. As a result, he reached the top 30 on 18 July 2022 and the top 25 a week later.

At the 2022 Hamburg European Open, he reached the quarterfinals defeating World No. 8 and second seed Andrey Rublev, his second Top-10 win. He reached his second ATP 500 semifinal by beating Aslan Karatsev in three sets.

He represented Argentina for the first time in the Davis Cup finals, where he lost both matches to Jannik Sinner and Borna Ćorić respectively.

Cerúndolo won his two first matches at a Grand Slam at the Australian Open after beating Guido Pella and Corentin Moutet to reach the third round on his debut at this Major.

He played again in the Davis Cup, this time recording his first win in the tournament against Otto Virtanen.

In Córdoba, Argentina he defeated fellow Argentine Federico Delbonis to reach the quarterfinals but lost to eventual runner-up compatriot Federico Coria, however, his brother Juanma defeated Diego Schwartzman in the same tournament, as a result, Francisco he became Argentine No. 1 and Latin American No. 1 player on 13 February 2023. In Buenos Aires, Argentina he defeated Yannick Hanfmann and Jaume Munar to reach back to back quarterfinals but lost to Bernabé Zapata Miralles. At the 2023 Rio Open he reached the round of 16 but lost again to Zapata Miralles. In Santiago he lost to eventual finalist fellow Argentine Tomás Martín Etcheverry in the first round.

In Miami he reached the fourth round again at this tournament, recording his first top-10 win of the season against fifth seed and world No. 6 Félix Auger-Aliassime and getting his revenge for his third round loss at the 2023 BNP Paribas Open two weeks earlier. He reached back-to-back quarterfinals at this tournament defeating Lorenzo Sonego.

In Barcelona he defeated world No. 3 Casper Ruud in the third round, his second top-10 win to reach the quarterfinals. In Madrid he lost in the second round to compatriot Pedro Cachin having a bye in the first round. In Rome he reached his second Masters quarterfinal of the season defeating Wu Yibing, Grégoire Barrère and world No. 8 Jannik Sinner, for his third top-10 win. In Lyon he reached a new ATP Tour final, beating Juan Pablo Varillas, Jack Draper, and Cameron Norrie, in the title match he lost against Arthur Fils in straight sets.

He picked up the second Major win of his career at the French Open, where he defeated Jaume Munar in four sets. Next he defeated lucky loser Yannick Hanfmann. He reached the round of 16 for the first time at a Major defeating ninth seed Taylor Fritz, his fourth top-10 win of the season. He lost to sixth seed Holger Rune in five sets with a fifth set tiebreaker. As a result, he reached the top 20 in the rankings on 12 June 2023.

In Eastbourne he became the third Argentinian champion on grass after Guillermo Vilas and Javier Frana, and the first since 1995, defeating Marc-Andrea Hüsler, Zhang Zhizhen, Mackenzie McDonald and second seed Tommy Paul, beating both Americans in the same day. He recorded his first win at the 2023 Wimbledon Championships defeating Nuno Borges.

On his return to clay at Båstad, he started his title defense beating Luca Van Assche in the second round, Federico Coria in the quarterfinals, but lost in the semifinals to eventual champion Andrey Rublev.

At the US Open he beat Zachary Svajda in the first round, his first win at this Major. On his debut at the Laver Cup he recorded the first ever win for South America at the event against Alejandro Davidovich Fokina. In Paris he reached the third round defeating Gaël Monfils and world No. 8 Casper Ruud, for his fifth top-10 win of the season.

The start of the season in the Australian Open Series began with three defeats in second rounds, first at Hong Kong Open, then at the ASB Classic, and the last at the Australian Open, where he lost against Fábián Marozsán in straight sets.

He was called up again for Argentina to play at the Davis Cup qualifying round, this time against Kazakhstan, he won the first match of the series against Dimitry Popko, giving his country the first point, after the defeat over Tomás Etcheverry and the victory over González/Molteni, Francisco lost against Timofey Skatov leaving the series 2-2, however, Sebastián Báez won against Popko and Argentina won the series 3-2, qualifying for the David Cup Finals.

Seeded fourth, he reached the semifinals at the ATP 500 2024 Rio Open for the second time at this tournament, but lost to fifth seed and eventual champion Sebastian Baez. He reached his fifth ATP final at the 2024 Croatia Open Umag defeating Lorenzo Sonego and upsetting top seed Andrey Rublev. He won his third title defeating second seed Lorenzo Musetti in three sets. In less than 24 hours, he recorded his first win at the Paris Olympics over Chilean Tomas Barrios Vera.

Seeded fourth, he reached the semifinals at the 2024 Almaty Open, but lost to Gabriel Diallo. At the 2024 Rolex Paris Masters Cerundolo again upset sixth seed Andrey Rublev in straight sets with two tiebreaks recording his 100th tour-level win. It was his fourth Top 10 win of the season and second over Rublev (after Umag).