HOU Astros

From 1888 until 1961, Houston's professional baseball club was the minor league Houston Buffaloes. Although expansion from the National League eventually brought an MLB team to Texas in 1962, Houston officials had been making efforts to do so for years prior, with a group effort led in 1952 to buy the St. Louis Cardinals for $4.25 million, but local owners were instead chosen. There were four men chiefly responsible for bringing Major League Baseball to Houston: journalist/promoter George Kirksey, Craig Cullinan Jr., R.E. "Bob" Smith, a prominent oilman and real estate magnate in Houston who like Cullinan was brought in for his financial resources, and Judge Roy Hofheinz, a former Mayor of Houston and Harris County Judge who was recruited for his salesmanship and political style. They founded the Houston Sports Association (HSA) as their vehicle for attaining a big league franchise for the city of Houston.

Given MLB's refusal to consider expansion, Kirksey, Cullinan, Smith, and Hofheinz joined forces with would-be owners from other cities and announced the formation of a new league to compete with the established National and American Leagues. They called the new league the Continental League. Wanting to protect potential new markets, both existing leagues chose to expand from eight teams to ten. However, plans eventually fell through for the Houston franchise after the Houston Buffaloes owner, Marty Marion, could not come to an agreement with the HSA to sell the team. To make matters worse, the Continental League as a whole folded in August 1960.

However, on October 17, 1960, the National League granted an expansion franchise to the Houston Sports Association for them to begin play in the 1962 season. According to the Major League Baseball Constitution, the Houston Sports Association was required to obtain territorial rights from the Houston Buffaloes in order to play in the Houston area, resulting in the HSA revisiting negotiations. Eventually, the Houston Sports Association succeeded in purchasing the Houston Buffaloes, which were at this point majority-owned by William Hopkins, on January 17, 1961. The Buffs played one last minor league season as the top farm team of the Chicago Cubs in 1961 before being succeeded by the city's NL club.

The new Houston team was named the Colt .45s after a "Name the Team" contest was won by William Irving Neder. The Colt .45 was well known as "the gun that won the west". The colors selected were navy and orange. The first team was formed mostly through an expansion draft after the 1961 season. The Colt .45s and their expansion cousins, the New York Mets, took turns choosing players left unprotected by the other National League franchises.

Many players and staff associated with the Houston Buffaloes organization continued in the major leagues. Manager Harry Craft, who had joined Houston in 1961, remained in the same position for the team until the end of the 1964 season. General manager Spec Richardson also continued with the organization as business manager but was later promoted back to GM for the Astros from 1967 until 1975. Although most players for the major league franchise were obtained through the 1961 Major League Baseball expansion draft, Buffs players J.C. Hartman, Pidge Browne, Jim Campbell, Ron Davis, Dave Giusti, and Dave Roberts were chosen to continue as major league ball players.

Similarly, the radio broadcasting team remained with the new Houston major league franchise. Loel Passe worked alongside Gene Elston as a color commentator until he retired from broadcasting in 1976. Elston continued with the Astros until 1986.

The Colt .45s began their existence playing at Colt Stadium, a temporary venue built just north of the construction site of their permanent home, a domed stadium. Hofheinz and his partners believed a domed stadium was a must for MLB to be viable in Houston, given the area's oppressive humidity.

The Colt .45s started their inaugural season on April 10, 1962, against the Chicago Cubs with Harry Craft as the Colt .45s' manager. Bob Aspromonte scored the first run for the Colt .45s on an Al Spangler triple in the first inning. They started the season with a three-game sweep of the Cubs but eventually finished eighth among the National League's ten teams. The team's best pitcher, Richard "Turk" Farrell, lost 20 games despite an ERA of 3.02. A starter for the Colt .45s, Farrell was primarily a relief pitcher prior to playing for Houston. He was selected to both All-Star Games in 1962.

The 1963 season saw more young talent mixed with seasoned veterans. Jimmy Wynn, Rusty Staub, and Joe Morgan all made their major league debuts in the 1963 season. However, Houston's position in the standings did not improve, as the Colt .45s finished in ninth place with a 66–96 record. The team was still building, trying to find that perfect mix to compete. The 1964 campaign began on a sad note, as relief pitcher Jim Umbricht died of cancer at the age of 33 on April 8, just before Opening Day. Umbricht was the only Colt .45s pitcher to post a winning record in Houston's first two seasons. He was so well liked by players and fans that the team retired his jersey number, 32, in 1965.

Just on the horizon, the structure of the new domed stadium was more prevalent and it would soon change the way that baseball was watched in Houston and around the league. On December 1, 1964, the team announced the name change from the Colt .45s to the "Astros".

With Judge Roy Hofheinz now the sole owner of the franchise and the new venue complete, the renamed Astros moved into their new domed stadium, the Astrodome, in 1965. The name honored Houston's position as the center of the nation's space program—NASA's new Manned Spacecraft Center had recently opened southeast of the city. The Astrodome, called the "Eighth Wonder of the World", did little to improve the home team's results on the field. While several "indoor" firsts were accomplished, the team still finished ninth in the standings. The attendance was high not because of the team's accomplishments, but because people came from miles around to see the Astrodome.

Just as the excitement was settling down over the Astrodome, the 1966 season found something new to put the domed stadium in the spotlight once again – the field. Grass would not grow in the new park, since the roof panels had been painted to reduce the glare that was causing players on both the Astros and the visiting teams to miss routine pop flies. A new artificial turf was created called "AstroTurf" and Houston would be involved in yet another change in the way the game was played.

With new manager Grady Hatton, the Astros started the 1966 season strong. By May they were in second place in the National League and looked like a team that could contend. Joe Morgan was named as a starter on the All-Star Team. The success did not last as they lost Jimmy Wynn for the season after he crashed into an outfield fence in Philadelphia and Morgan had broken his knee cap. The 1967 season saw first baseman Eddie Mathews join the Astros. The slugger hit his 500th home run while in Houston. He would be traded late in the season and Doug Rader would be promoted to the big leagues. Rookie Don Wilson pitched a no-hitter on June 18. Wynn also provided some enthusiasm in 1967. The 5 ft 9 in Wynn was becoming known not only for how often he hit home runs, but also for how far he hit them. Wynn set club records with 37 home runs, and 107 RBIs. It was also in 1967 that Wynn hit his famous home run onto Interstate 75 in Cincinnati. As the season came to a close, the Astros found themselves again in ninth place and with a winning percentage below .500. The team looked good on paper, but could not make it work on the field.

April 15, 1968, saw a pitching duel for the ages. The Astros' Don Wilson and the Mets' Tom Seaver faced each other in a battle that lasted six hours. Seaver went ten innings, allowing no walks and just two hits. Wilson went nine innings, allowing five hits and three walks. After the starters exited, eleven relievers (seven for the Mets and four for the Astros) tried to end the game. The game finally ended in the 24th inning when Bob Aspromonte hit a shot toward Mets shortstop Al Weis. Weis had been perfect all night at short, but he was not quick enough to make the play. The ball zipped into left field, allowing Norm Miller to score.

With baseball expansion and trades, the Astros had dramatically changed in 1969. Aspromonte was sent to the Braves and Rusty Staub was traded to the expansion Montreal Expos, in exchange for outfielder Jesús Alou and first baseman Donn Clendenon. However, Clendenon refused to report to Houston, electing to retire and take job with a pen manufacturing company. The Astros asked Commissioner Bowie Kuhn to void the trade, but he refused. Instead, he awarded Jack Billingham and a left-handed relief pitcher to the Astros to complete the trade. Cuellar was traded to the Baltimore Orioles for Curt Blefary. Other new players included catcher Johnny Edwards, infielder Denis Menke and pitcher Denny Lemaster. Wilson continued to pitch brilliantly and on May 1 threw the second no-hitter of his career. In that game, he struck out 18 batters, tying what was then the all-time single-game mark. He was just 24 years of age and was second to only Sandy Koufax for career no-hit wins. Wilson's no-hitter lit the Astros' fire after a miserable month of April, and six days later the team tied a major league record by turning seven double plays in a game. By May's end, the Astros had put together a ten-game winning streak. The Houston infield tandem of Menke and Joe Morgan continued to improve, providing power at the plate and great defense. Morgan had 15 homers and stole 49 bases while Menke led the Astros with 90 RBIs. The Menke/Morgan punch was beginning to come alive, and the team was responding to Walker's management style. The Astros dominated the season series against their expansion twins, the New York Mets. In one game at New York, Denis Menke and Jimmy Wynn hit grand slams in the same inning, against a Mets team that would go on to win the World Series that same year. The Astros finished the 1969 season with a record of 81 wins, 81 losses, marking their first season of .500 ball.

In 1970, the Astros were expected to be a serious threat in the National League West. In June, 19-year-old César Cedeño was called up and immediately showed signs of being a superstar. The Dominican outfielder batted .310 after being called up. Not to be outdone, Menke batted .304 and Jesús Alou batted .306. The Astros' batting average was up by 19 points compared to the season before. The team looked good, but the Astros' ERA was up. Larry Dierker and Wilson had winning records, but the pitching staff as a whole had an off season. Houston finished in fourth place in 1970.

The fashion trends of the 1970s had started taking root in baseball. Long hair and loud colors were starting to appear on team uniforms, including the Astros'. In 1971 the Astros made some changes to their uniform: they kept the same style they had in previous seasons, but inverted the colors. What was navy was now orange and what was orange was now a lighter shade of blue. The players' last names were added to the back of the jerseys. In 1972, the uniform fabric was also changed to what was at the time revolutionizing the industry – polyester. Belts were replaced by elastic waistbands, and jerseys zipped up instead of having buttons. The uniforms became popular with fans, but would last only until 1975, when the Astros would shock baseball and the fashion world.

The uniforms were about the only thing that did change in 1971. The acquisition of Roger Metzger from the Chicago Cubs in the off-season moved Menke to first base and Bob Watson to the outfield. The Astros got off to a slow start and the pitching and hitting averages were down. Larry Dierker was selected to the All-Star Game in 1971, but due to an arm injury he could not make it. César Cedeño led the club with 81 RBIs and the league with 40 doubles, but batted just .264 and had 102 strikeouts in his second season with the Astros. Pitcher J. R. Richard made his debut in September of the 1971 season against the Giants.

In November 1971 the Astros and Cincinnati Reds made one of the biggest blockbuster trades in the history of the sport, and helped create The Big Red Machine of the 1970s, with the Reds getting the better end of the deal. Houston sent second baseman Joe Morgan, infielder Denis Menke, pitcher Jack Billingham, outfielder César Gerónimo and prospect Ed Armbrister to Cincinnati for first baseman Lee May, second baseman Tommy Helms and infielder Jimmy Stewart. The trade left Astros fans and the baseball world scratching their heads as to why general manager Spec Richardson would give up so much for so little. The Reds, on the other hand, would shore up many problems. They had an off year in 1971, but were the National League Pennant winner in 1972.

The Astros' acquisition of Lee May added more power to the lineup in 1972. May, Wynn, Rader and Cedeño all had 20 or more home runs and Watson hit 16. Cedeño also led the Astros with a .320 batting average, 55 stolen bases and made spectacular plays on the field. Cedeño made his first All-Star game in 1972 and became the first Astros player in team history to hit for the cycle in August versus the Reds. The Astros finished the strike-shortened season at 84–69, their first winning season.

Astros fans had hoped for more of the same in 1973, but it was not to be. The Astros run production was down, even though the same five sluggers the year before were still punching the ball out of the park. Lee May led the Astros with 28 home runs and Cesar Cedeño batted .320 with 25 home runs. Bob Watson hit the .312 mark and drove in 94 runs. Doug Rader and Jimmy Wynn both had 20 or more home runs. However, injuries to their pitching staff limited the Astros to an 82–80 fourth-place finish. The Astros again finished in fourth place the next year under new manager Preston Gómez.

With the $38 million deficit of the Astrodome, control of the Astrodomain (including the Astros) was passed from Roy Hofheinz to GE Credit and Ford Motor Credit. The creditors were just interested in preserving asset value of the team, so any money spent had to be found or saved somewhere else. Tal Smith returned to the Astros from the New York Yankees to find a team that needed a lot of work and did not have a lot of money. However, there would be some bright spots that would prove to be good investments in the near future.

The year started on a sad note. Pitcher Don Wilson was found dead in the passenger seat of his car on January 5, 1975; the cause of death was asphyxiation by carbon monoxide. Wilson was 29 years old. Wilson's number 40 was retired on April 13, 1975.

The 1975 season saw the introduction of the Astros' new uniforms. Many teams were going away from the traditional uniform and the Astros were no exception. From the chest down, the uniform was a solid block of yellow, orange, and red stripes. There was also a large dark blue star over the midsection. The same multi-colored stripes ran down the pant legs. Players' numbers not only appeared on the back of the jersey, but also on the pant leg. The bright stripes were meant to appear as a fiery trail like a rocket sweeping across the heavens. The uniforms were panned by critics, but the public liked them and versions started appearing at the high school and little league level. The uniform was so different from what other teams wore that the Astros wore it both at home and on the road until 1980.

Besides the bright new uniforms there were some other changes. Lee May was traded to Baltimore for much talked about rookie second baseman Rob Andrews and utility player Enos Cabell. In Baltimore, Cabell was stuck behind third baseman Brooks Robinson, but he took advantage of his opportunity in Houston and became their everyday third baseman. Cabell would go on to become a big part of the team's success in later years. With May gone, Bob Watson was able to move to first base and was a bright spot in the line up, batting .324 with 85 RBI.

The two biggest moves the Astros made in the offseason were the acquisitions of Joe Niekro and José Cruz. The Astros bought Niekro from the Braves for almost nothing. Niekro had bounced around the big leagues with minimal success. His older brother Phil Niekro had started teaching Joe how to throw his knuckleball and Joe was just starting to use it when he came to the Astros. Niekro won six games, saved four games and had an ERA of 3.07. Acquiring José Cruz from the Cardinals was another big win. Cruz became a fixture in the Astros' outfield for several years and would eventually have his number 25 retired.

Despite high expectations, 1975 was among the Astros' worst in franchise history. Their record of 64–97 was far worse than even the expansion Colt .45's and would remain the worst record in franchise history until 2011. It was the worst record in baseball and manager Preston Gómez was fired late in the season and replaced by Bill Virdon. The Astros played .500 ball under Virdon in the last 34 games of the season. With Virdon as the manager the Astros improved greatly in 1976 finishing in third place with an 80–82 record. A healthy César Cedeño was a key reason for the Astros' success in 1976. Bob Watson continued to show consistency and led the club with a .313 average and 102 RBI. José Cruz became Houston's everyday left fielder and hit .303 with 28 stolen bases. 1976 saw the end of Larry Dierker's playing career as an Astro, but before it was all over he would throw a no-hitter and win the 1,000th game in the Astrodome. The Astros finished in third place again in 1977 with a record of 81–81.

One of the big problems the Astros had in the late 1970s was that they were unable to compete in the free-agent market. Ford Motor Credit Company was still in control of the team and was looking to sell the Astros, but would not spend money on better players. Most of the talent was either farm grown or bought cheaply.

The 1979 season would prove to be a big turnaround in Astros history. During the offseason, the Astros attempted to fix some of their problem areas. They traded Floyd Bannister to Seattle for shortstop Craig Reynolds and acquired catcher Alan Ashby from Toronto for pitcher Mark Lemongello. Reynolds and Ashby were both solid in their positions and gave Houston some much-needed consistency. The season started with a boost from pitcher Ken Forsch, who threw a no-hitter against the Braves the second game of the season. In May 1979, New Jersey shipping tycoon John McMullen had agreed to buy the Astros. Now with an investor in charge, the Astros would be more likely to compete in the free-agent market.

The Astros were playing great baseball throughout the season. José Cruz and Enos Cabell both stole 30 bases. Joe Niekro had a great year with 21 wins and 3.00 ERA. J. R. Richard won 18 games and set a new personal strikeout record at 313. Joe Sambito came into his own with 22 saves as the Astros closer. Things were going as they should for a team that could win the west. The Astros and Reds battled the final month of the season. The Reds pulled ahead of the Astros by a game and a half. Later that month they split a pair and the Reds kept the lead. The Astros finished with their best record to that point at 89–73 and 1+1⁄2 games behind the NL winner Reds.

With Dr. McMullen as sole owner of the Astros, the team would now benefit in ways a corporation could not give them. The rumors of the Astros moving out of Houston started to crumble and the Astros were now able to compete in the free-agent market. McMullen showed the city of Houston that he too wanted a winning team, signing nearby Alvin, Texas native Nolan Ryan to the first million-dollar-a-year deal. Ryan had four career no-hitters already and had struck out 383 in one season.

Joe Morgan returned in 1980. The 1980 pitching staff was one of the best Houston ever had, with the fastball of Ryan, the knuckleball of Joe Niekro and the terrifying 6 ft 8 in frame of J. R. Richard. Teams felt lucky to face Ken Forsch, who was a double-digit winner in the previous two seasons. Richard became the first Astros pitcher to start an All-Star game. Three days later, Richard was told to rest his arm after a medical examination and on July 30 he collapsed during a workout. He had suffered a stroke after a blood clot in the arm apparently moved to his neck and cut off blood flow to the brain. Surgery was done to save his life, but the Astros had lost their ace pitcher after a 10–4 start with a stingy 1.89 ERA. Richard attempted a comeback, but would never again pitch a big league game.

After the loss of Richard and some offensive struggles, the Astros slipped to third place in the division behind the Dodgers and the Reds. They bounced back to first with a ten-game winning streak, but the Dodgers regained a two-game lead before arriving in Houston on September 9. The Astros won the first two games of the series to tie the Dodgers for the division lead. The Astros went on to win a third game and take the lead- with three games against the Dodgers left. The Dodgers swept the next series, forcing a one-game playoff the next day. The Astros won the playoff game 7–1, and advanced to their first post-season.

The team would face the Philadelphia Phillies in the 1980 National League Championship Series. The Phillies sent out Steve Carlton in game one of the NLCS. The Phillies would win the opener after the Astros got out to a 1–0 third-inning lead. Ken Forsch pitched particularly strong fourth and fifth innings, but Greg Luzinski hit a sixth-inning two-run bomb to the 300 level seats of Veterans Stadium. The Phillies added an insurance run on the way to a 3–1 win. Houston bounced back to win games two and three. Game four went into extra innings, with the Phillies taking the lead and the win in the tenth inning. Pete Rose started a rally with a one-out single, then Luzinski doubled off the left-field wall and Rose bowled over catcher Bruce Bochy to score the go-ahead run. The Phillies got an insurance run on the way to tying the series.

Rookie Phillies pitcher Marty Bystrom was sent out by Philadelphia manager Dallas Green to face veteran Nolan Ryan in Game Five. The rookie gave up a run in the first inning, then held the Astros at bay until the sixth inning. An Astros lead was lost when Bob Boone hit a two-out single in the second, but the Astros tied the game in the sixth with an Alan Ashby single scoring Denny Walling. Houston took a 5–2 lead in the seventh; however, the Phillies came back with five runs in the inning. The Astros came back against Tug McGraw with four singles and two two-out runs. Now in extra innings, Garry Maddox doubled in Del Unser with one out to give the Phillies an 8–7 lead. The Astros failed to score in the bottom of the tenth.

A 1981 player strike ran between June 12 and August 10. Ultimately, the strike would help the Astros get into the playoffs. Nolan Ryan and Bob Knepper picked up steam in the second half of the season. Ryan threw his fifth no-hitter on September 26 and finished the season with a 1.69 ERA. Knepper finished with an ERA of 2.18. In the wake of the strike, Major League Baseball took the winners of each "half" season and set up a best-of-five divisional playoff. The Reds won more games than any other team in the National League, but they won neither half of the strike-divided season. The Astros finished 61–49 overall, which would have been third in the division behind the Reds and the Dodgers. Advancing to the playoffs as winners of the second half, Houston beat Los Angeles in their first two playoff games at home, but the Dodgers took the next three in Los Angeles to advance to the NLCS.

By 1982, only four players and three starting pitchers remained from the 1980 squad. The Astros were out of pennant contention by August and began rebuilding for the near future. Bill Virdon was fired as manager and replaced by original Colt .45 Bob Lillis. Don Sutton asked to be traded and was sent to the Milwaukee Brewers for cash and the team gained three new prospects, including Kevin Bass. Minor league player Bill Doran was called up in September. The Astros finished fourth in the west, but new talent was starting to appear.

Before the 1983 season, the Astros traded Danny Heep to the Mets for pitcher Mike Scott, a 28-year-old who had struggled with New York. Art Howe sat out the 1983 season with an injury, forcing Phil Garner to third and Ray Knight to first. Doran took over at second, becoming the everyday second baseman for the next seven seasons. The Astros finished third in the National League West. The 1984 season started off badly when shortstop Dickie Thon was hit in the head by a pitch and was lost for the season. In September, the Astros called up rookie Glenn Davis after he posted impressive numbers in AAA. The Astros finished in second place. In 1985, Mike Scott learned a new pitch, the split-finger fastball. Scott, who was coming off of a 5–11 season, had found his new pitch and would become one of Houston's most celebrated hurlers. In June, Davis made the starting lineup at first base, adding power to the team. In September, Joe Niekro was traded to the Yankees for two minor league pitchers and lefty Jim Deshaies. The Astros finished in fourth place in 1985.

After finishing fourth in 1985, the Astros fired general manager Al Rosen and manager Bob Lillis. The former was supplanted by Dick Wagner, the man whose Reds defeated the Astros to win the 1979 NL West title. The latter was replaced by Hal Lanier who, like his manager mentor in St. Louis, Whitey Herzog, had a hard-nosed approach to managing and espoused a playing style that focused on pitching, defense, and speed rather than home runs to win games. This style of baseball, known as Whiteyball, took advantage of stadiums with deep fences and artificial turf, both of which were characteristics of the Astrodome. Lanier's style of baseball took Houston by storm. Before Lanier took over, fans were accustomed to Houston's occasional slow starts, but with Lanier leading the way, Houston got off to a hot start, winning 13 of their first 19 contests.

Prior to the start of the season the Astros acquired outfielder Billy Hatcher from the Cubs for Jerry Mumphrey. Lainer also made a change in the pitching staff, going with a three-man rotation to start the season. This allowed Lanier to keep his three starters (Nolan Ryan, Bob Knepper, and Mike Scott) sharp and to slowly work in rookie hurler Jim Deshaies. Bill Doran and Glenn Davis held down the right side of the field but Lainer rotated the left side. Denny Walling and Craig Reynolds faced the right-handed pitchers while Phil Garner and Dickie Thon batted against left-handers. Lanier knew the Astros had talent and he put it to work.

The Astrodome was host to the 1986 All-Star Game in which Astros Mike Scott, Kevin Bass, Glenn Davis, and Dave Smith represented the host field. The Astros kept pace with the NL West after the All-Star break. They went on a streak of five straight come-from-behind wins. Houston swept a key 3-game series over the San Francisco Giants in late September to clinch the division title. Mike Scott took the mound in the final game of the series and pitched a no-hitter – the only time in MLB history that any division was clinched via a no-hitter. Scott would finish the season with an 18–10 record and a Cy Young Award.

The 1986 National League Championship Series against the New York Mets was noted for its drama and is considered to be one of the greatest postseason series. In Game 3, the Astros were ahead at Shea Stadium, 5–4, in the bottom of the 9th when closer Dave Smith gave up a two-run home run to Lenny Dykstra, giving the Mets a dramatic 6–5 win.

However, the signature game of the series was Game 6. Needing a win to get to Mike Scott (who had been dominant in the series) in Game 7, the Astros jumped off to a 3–0 lead in the first inning but neither team would score again until the 9th inning. In the 9th, starting pitcher Bob Knepper would give up two runs, and once again the Astros would look to Dave Smith to close it out. However, Smith would walk Gary Carter and Darryl Strawberry, giving up a sacrifice fly to Ray Knight, tying the game. Despite having the go-ahead runs on base, Smith was able to escape the inning without any further damage.

There was no scoring until the 14th inning when the Mets would take the lead on a Wally Backman single and an error by left fielder Billy Hatcher. The Astros would get the run back in the bottom of the 14th when Hatcher (in a classic goat-to-hero-conversion-moment) hit one of the most dramatic home runs in NLCS history, off the left-field foul pole. In the 16th inning, Darryl Strawberry doubled to lead off the inning and Ray Knight drove him home in the next at-bat. The Mets would score a total of three runs in the inning to take what appeared an insurmountable 7–4 lead. With their season on the line, the Astros would nonetheless rally for two runs to come to within 7–6. Kevin Bass came up with the tying and winning runs on base; however Jesse Orosco would strike him out, ending the game. At the time the 16-inning game held the record for the longest in MLB postseason history. The Mets won the series, 4–2.

After the 1986 season, the team had difficulty finding success again. Several changes occurred. The "rainbow" uniforms were phased out, the team electing to keep a five-stripe "rainbow" design on the sleeves. Team favorites Nolan Ryan and José Cruz moved on and the team entered a rebuilding phase. Craig Biggio debuted in June 1988, joining new prospects Ken Caminiti and Gerald Young. Biggio would become the everyday catcher by 1990. A trade acquiring Jeff Bagwell in exchange for Larry Andersen would become one of the biggest deals in Astros history. Glenn Davis was traded to Baltimore for Curt Schilling, Pete Harnisch and Steve Finley in 1990.

The early 1990s were marked by the Astros' growing discontent with their home, the Astrodome. After the Astrodome was renovated for the primary benefit of the NFL's Houston Oilers (who shared the Astrodome with the Astros since the 1960s), the Astros began to grow increasingly disenchanted with the facility. Faced with declining attendance at the Astrodome and the inability of management to obtain a new stadium, in the 1991 off-season Astros management announced its intention to sell the team and move the franchise to the Washington, D.C. area. However, the move was not approved by other National League owners, thus compelling the Astros to remain in Houston. Shortly thereafter, McMullen (who also owned the NHL's New Jersey Devils) sold the team to Texas businessman Drayton McLane in 1993, who committed to keeping the team in Houston.

Shortly after McLane's arrival, which coincided with the maturation of Bagwell and Biggio, the Astros began to show signs of consistent success. After finishing second in their division in 1994 (in a strike year), 1995, and 1996, the Astros won consecutive division titles in 1997, 1998, and 1999. In the 1998 season, the Astros set a team record with 102 victories. However, each of these titles was followed by a first-round playoff elimination, in 1998 by the San Diego Padres and in 1997 and 1999 against the Atlanta Braves. The manager of these title teams was Larry Dierker, who had previously been a broadcaster and pitcher for the Astros. During this period, Bagwell, Biggio, Derek Bell, and Sean Berry earned the collective nickname "The Killer Bs". In later seasons, the name came to include other Astros, especially Lance Berkman.

Coinciding with the change in ownership, the team switched uniforms and team colors after the 1993 season in order to go for a new, more serious image. The team's trademark rainbow uniforms were retired, and the team's colors changed to midnight blue and metallic gold. The "Astros" font on the team logo was changed to a more aggressive one, and the team's traditional star logo was changed to a stylized, "flying" star with an open left end. It marked the first time since the team's inception that orange was not part of the team's colors. Despite general agreement that the rainbow uniforms identified with the team had become tired (and looked too much like a minor league team according to the new owners), the new uniforms and caps were never especially popular with many Astros fans.

Off the field, in 1994, the Astros hired one of the first African American general managers, former franchise player Bob Watson. Watson would leave the Astros after the 1995 season to become general manager of the New York Yankees and helped to lead the Yankees to a World Series championship in 1996. He would be replaced by Gerry Hunsicker, who until 2004 would continue to oversee the building of the Astros into one of the better and most consistent organizations in the Major Leagues.

However, in 1996, the Astros again nearly left Houston. By the mid-1990s, McLane (like McMullen before him) wanted his team out of the Astrodome and was asking the city to build the Astros a new stadium. When things did not progress quickly toward that end, he put the team up for sale. He had nearly finalized a deal to sell the team to businessman William Collins, who planned to move them to Northern Virginia. However, Collins was having difficulty finding a site for a stadium himself, so Major League owners stepped in and forced McLane to give Houston another chance to grant his stadium wish. Houston voters, having already lost the Houston Oilers in a similar situation, responded positively via a stadium referendum and the Astros stayed put.

The 2000 season saw a move to a new stadium. Originally to be named The Ballpark at Union Station due to being located on the site of Union Station, it was renamed Enron Field by the season opening after the naming rights were sold to energy corporation Enron. The stadium was to feature a retractable roof, a particularly useful feature with unpredictable Houston weather. The ballpark also featured more intimate surroundings than the Astrodome. In 2002, naming rights were purchased by Houston-based Minute Maid, after Enron went bankrupt. The park was built on the grounds of the old Union Station. A replica 4-4-0 locomotive moves across the outfield and whistles after home runs, paying homage to a Houston history which had 11 railroad company lines running through the city by 1860. The ballpark previously contained quirks such as "Tal's Hill", which was a hill in deep center field on which a flagpole stood, all in fair territory. Over the years, many highlight reel catches have been made by center fielders running up the hill to make catches. Tal's Hill was removed in the 2016–2017 offseason and the center field wall was moved in to 409 feet (125 m), which the team hoped would generate more home runs.

With the change in location also came a change in attire. Gone were the blue and gold uniforms of the 1990s in favor of a more "retro" look with pinstripes, a traditional baseball font, and the colors of brick red, sand and black. These colors were chosen because ownership originally wanted to rename the team the Houston Diesels. The "shooting star" logo was modified but still retained its definitive look.

After two fairly successful seasons without a playoff appearance, the Astros were early favorites to win the 2004 NL pennant. They added star pitcher Andy Pettitte to a roster that already included standouts like Lance Berkman and Jeff Kent as well as veterans Bagwell and Biggio. Roger Clemens, who had retired after the 2003 season with the New York Yankees, agreed to join former teammate Pettitte on the Astros for 2004. The one-year deal included unique conditions, such as the option for Clemens to stay home in Houston on select road trips when he wasn't scheduled to pitch. Despite the early predictions for success, the Astros had a mediocre 44–44 record at the All-Star break. A lack of run production and a poor record in close games were major issues. After being booed at the 2004 All-Star Game held in Houston, manager Jimy Williams was fired and replaced by Phil Garner, a star on the division-winning 1986 Astros. The Astros enjoyed a 46–26 record in the second half of the season under Garner and earned the NL wild-card spot. The Astros defeated the Braves 3–2 in the Division Series, but would lose the National League Championship Series to the St. Louis Cardinals in seven games. Clemens earned a record seventh Cy Young Award in 2004. Additionally, the mid-season addition of Carlos Beltrán in a trade with the Kansas City Royals helped the Astros tremendously in their playoff run. Despite midseason trade rumors, Beltrán would prove instrumental to the team's hopes, hitting eight home runs in the postseason. Though he had asserted a desire to remain with the Astros, Beltrán signed a long-term contract with the New York Mets on January 9, 2005.

In 2005, the Astros started poorly and found themselves with a 15–30 record in late May. The Houston Chronicle had written them off with a tombstone emblazoned with "RIP 2005 Astros". However, from that low point until the end of July, Houston went 42–17 and found themselves in the lead for an NL wild card spot. July saw the best single-month record in the club's history at 22–7. Offensive production had increased greatly after a slow start in the first two months. The Astros had also developed an excellent pitching staff, anchored by Roy Oswalt (20–12, 2.94), Andy Pettitte (17–9, 2.39), and Roger Clemens (13–8 with a league-low ERA of only 1.87). The contributions of the other starters—Brandon Backe (10–8, 4.76) and rookie starters Ezequiel Astacio (3–6, 5.67) and Wandy Rodríguez (10–10, 5.53)—were less remarkable, but enough to push the Astros into position for a playoff run. The Astros won a wild card berth on the final day of the regular season, becoming the first team since the World Series champion 1914 Boston Braves to qualify for the postseason after being 15 games under .500.

The Astros won the National League Division Series against the Atlanta Braves, 3–1, with a game four that set postseason records for most innings (18), most players used by a single team (23), and longest game time (5 hours and 50 minutes). Trailing by a score of 6–1, Lance Berkman hit an eighth-inning grand slam to narrow the score to 6–5. In the bottom of the ninth, catcher Brad Ausmus hit a game-tying home run that allowed the game to continue in extra innings. In the bottom of the tenth inning, Luke Scott hit a blast to left field that had home run distance, but was inches foul. This game remained scoreless for the next eight innings. In the top of the 15th inning, Roger Clemens made only his second career relief appearance, pitching three shutout innings, notably striking out Julio Franco, at the time the oldest player in MLB at 47 years old; Clemens was himself 43. In the bottom of the eighteenth inning, Clemens came to bat again, indicating that he would be pitching in the nineteenth inning, if it came to that. Clemens struck out, but the next batter, Chris Burke, hit a home run to left field to send the Astros to a 7–6 victory. The National League Championship Series featured a rematch of the 2004 NLCS. The Astros lost the first game in St. Louis, but would win the next three games. Though the Astros were poised to close out the series in Game Five in Houston, Brad Lidge gave up a monstrous two-out three-run home run to Albert Pujols, forcing the series to a sixth game in St. Louis, where the Astros clinched a World Series appearance. Roy Oswalt was named NLCS MVP, having gone 2–0 with a 1.29 ERA in the series. Honorary National League President Bill Giles presented the league champion Astros with the Warren C. Giles Trophy (named for his father) for winning the series; the younger Giles had been one of the founders of the original Colt 45 team in 1962, while his father Warren had been president of the National League from 1951 to 1969.

The Astros faced the Chicago White Sox in the World Series. Chicago had been considered the slight favorite but would win all four games, the first two at U.S. Cellular Field in Chicago and the final two in Houston. Game 3 marked the first World Series game held in the state of Texas, and was the longest game in World Series history, lasting 5 hours and 41 minutes.

This World Series was marked by a controversy involving the Minute Maid Park roof. MLB and Commissioner Bud Selig insisted that the Astros must play with the roof open, which mitigated the intensity and enthusiasm of the cheering Astros fans.

In the 2006 offseason, the team signed Preston Wilson and moved Berkman to first base, ending the long tenure of Jeff Bagwell. The Astros renewed the contract with Clemens and traded two minor league prospects to the Tampa Bay Devil Rays for left-handed hitter Aubrey Huff. By August, Preston Wilson complained about his playing time after the return of Luke Scott from AAA Round Rock. The Astros released Wilson and he was signed by St. Louis. A dramatic season end included wins in 10 of their last 12 games, but the Astros missed a playoff appearance when they lost the final game of the season to the Atlanta Braves.

On October 31, the Astros declined a contract option on Jeff Bagwell for 2007, ending his 15-year Astros career and leading to his retirement. Roger Clemens and Andy Pettitte filed for free agency. On December 12, the Astros traded Willy Taveras, Taylor Buchholz, and Jason Hirsh to the Colorado Rockies for Rockies pitchers Jason Jennings and Miguel Asencio. A trade with the White Sox, involving the same three Astros in exchange for Jon Garland, had been nixed a few days earlier when Buchholz reportedly failed a physical. In the end, Taveras continued to develop and Hirsh had a strong 2007 rookie campaign, while Jennings was often injured and generally ineffective.

On April 28, 2007, the Astros purchased the contract of top minor league prospect Hunter Pence. He debuted that night, getting a hit and scoring a run. By May 2007, the Astros had suffered one of their worst losing streaks (10 games). On June 28, second baseman Craig Biggio became the 27th MLB player to accrue 3,000 career hits. Biggio needed three hits to reach 3,000 and ended the night with a total of five hits. That night, Carlos Lee hit a towering walk-off grand slam in the 11th inning. Lee later quipped to the media that "he had hit a walk-off grand slam and he got second billing", considering Biggio's achievement. On July 24, Biggio announced that he would retire at the end of the season. He hit a grand slam in that night's game which broke a 3–3 tie and led to an Astros win. In Biggio's last at bat, he grounded out to Chipper Jones of the Atlanta Braves.

On September 20, Ed Wade was named general manager. In his first move, he traded Jason Lane to the Padres on September 24. On September 30, Craig Biggio retired after twenty years with the team. In November, the Astros traded RHP Brad Lidge and SS Eric Bruntlett to the Philadelphia Phillies for OF Michael Bourn, RHP Geoff Geary, and minor leaguer Mike Costanzo. Utility player Mark Loretta accepted Houston's salary arbitration and Kazuo Matsui finalized a $16.5 million, three-year contract with the team. In December, the Astros traded OF Luke Scott, RHP Matt Albers, RHP Dennis Sarfate, LHP Troy Patton, and minor-league 3B Mike Costanzo, to the Baltimore Orioles for SS Miguel Tejada. On December 14, they sent infielder Chris Burke, RHP Juan Gutiérrez, and RHP Chad Qualls to the Arizona Diamondbacks for RHP José Valverde. On December 27, the Astros came to terms on a deal with All-Star, Gold Glove winner Darin Erstad.

In January and February 2008, the Astros signed Brandon Backe, Ty Wigginton, Dave Borkowski and Shawn Chacón to one-year deals. The starting rotation would feature Roy Oswalt and Brandon Backe as numbers one and two. Wandy Rodríguez, Chacón and Chris Sampson rounded out the bottom three slots in the rotation. Woody Williams had retired after a 0–4 spring training and Jason Jennings was now with Texas. On the other side of the roster, the Astros would start without Kazuo Matsui, who was on a minor league rehab assignment after a spring training injury.

The Astros regressed in 2008 and 2009, finishing with records of 86–75 and 74–88, respectively. Manager Cecil Cooper was fired after the 2009 season. At the lowest point of the regression, child admission was free.

The 2010 season was the first season as Astros manager for Brad Mills, who was previously the bench coach of the Boston Red Sox. The Astros struggled throughout a season that was marked by trade-deadline deals that sent longtime Astros to other teams. On July 29, the Astros' ace starting pitcher, Roy Oswalt, was dealt to the Philadelphia Phillies for J. A. Happ and two minor league players. On July 31, outfielder Lance Berkman was traded to the New York Yankees for minor leaguers Jimmy Paredes and Mark Melancon. The Astros finished with a record of 76–86.

On July 30, 2011, the Astros traded OF Hunter Pence, the team's 2010 leader in home runs, to the Philadelphia Phillies. On July 31, they traded OF Michael Bourn to the Atlanta Braves. On September 17, the Astros recorded their first 100-loss season in franchise history, ending the season eleven days later with an 8–0 home loss to the St. Louis Cardinals. Cardinals pitcher Chris Carpenter pitched a two-hit complete game shutout. The Cardinals would go on to win the National League Wild Card, before beating the Texas Rangers in the World Series. Lance Berkman, who was now a Cardinal, was a key player in their championship victory. The Astros finished with a record of 56–106, the worst single-season record in franchise history (a record which would be broken the following season).

In November 2010, Drayton McLane announced that the Astros were being put up for sale. McLane stated that because the Astros were one of the few franchises in Major League Baseball with only one family as the owners, he was planning his estate. McLane was 75 years old as of November 2011. In March 2011, local Houston businessman Jim Crane emerged as the front-runner to purchase the franchise. In the 1980s, Crane founded an air freight business which later merged with CEVA Logistics, and later founded Crane Capital Group. McLane and Crane had a previous handshake agreement for the franchise in 2008, but Crane abruptly changed his mind and broke off discussions. Crane also attempted to buy the Chicago Cubs in 2008 and the Texas Rangers during their 2010 bankruptcy auction. Crane came under scrutiny because of previous allegations of discriminatory hiring practices regarding women and minorities, among other issues. This delayed MLB's approval process. In the summer of 2011, Crane claimed those issues had been resolved, and suggested that the delays were baseball's attempt to move the Astros to the American League. In October later that year, Crane met personally with MLB Commissioner Bud Selig, in a meeting that was described as "constructive".

On November 15, 2011, it was announced that Crane had agreed to move the franchise to the American League for the 2013 season. The move was part of an overall divisional realignment of MLB, with the National and American leagues each having 15 teams in three geographically balanced divisions. Crane was given a $70 million concession by MLB for agreeing to the switch; the move was a condition for the sale to the new ownership group. Two days later, the Astros were officially sold to Crane for $615 million after the other owners unanimously voted in favor of the sale. It was also announced that 2012 would be the last season for the Astros in the NL. After over fifty years of the Astros being a part of the National League, this move was unpopular with many Astros fans. In December 2011, Jeff Luhnow was named general manager.

In 2012, the Astros were eliminated from the playoffs before September 5. On September 27, the Astros named Bo Porter to be the manager for the 2013 season.

On October 3, the Astros ended over 50 years of NL play with a 5–4 loss to the Chicago Cubs and began to look ahead to join the American League. Winning only 20 road games during the entire season, the Astros finished with a 55–107 record, the worst record in all of Major League Baseball for the 2012 season, and surpassing the 2011 season for the worst record in Astros history.

On November 2, 2012, the Astros unveiled their new look in preparation for their move to the American League for the 2013 season. The navy and orange uniform returned to the original 1960s team colors, and debuted a new version of the classic navy hat with a white "H" over an orange star.

On November 6, 2012, the Astros hired former Cleveland Indians director of baseball operations David Stearns as the team's new assistant general manager.

The Houston Astros played their first game as an American League team on March 31, 2013, where they were victorious over their in-state division competitor, the Texas Rangers, with a score of 8–2.

On May 17, Reid Ryan, son of Nolan Ryan was introduced as president of operations.

On September 29, the Astros completed their first year in the American League, losing 5–1 in a 14-inning game to the New York Yankees. The Astros finished the season with a 51–111 record (a franchise-worst) with a season-ending 15-game losing streak, again surpassing their worst record from the previous season. The team finished 45 games behind the division winner Oakland Athletics, further adding to their futility. This marked three consecutive years that the Astros had lost more than 100 games in a single season. They also became the first team to have the first overall pick in the draft three years in a row.

In February 2014, Nolan Ryan rejoined the Astros front office as assistant to owner Jim Crane, GM Jeff Luhnow and president of business operations Reid Ryan. From 2004 through 2008 he worked as a special assistant to the GM.

For the 2014 season the team went 70–92, finishing 28 games back of the division winner Los Angeles Angels of Anaheim, and placing fourth in the AL West over the Texas Rangers.

A. J. Hinch was named manager on September 29, replacing Bo Porter, who was fired on September 1.

In 2015, Dallas Keuchel led the AL with 20 victories, going 15–0 at home, an MLB record. Key additions to the team included Scott Kazmir and SS Carlos Correa who hit 22 home runs after being called up in June 2015. Second baseman Jose Altuve remained the star of the Astros' offense. On July 30, the Astros picked up Mike Fiers and Carlos Gómez from the Milwaukee Brewers. Fiers threw the 11th no-hitter in Astros history on August 21 against the Los Angeles Dodgers. Houston got the final AL playoff spot and faced the Yankees in the Wild Card Game on October 6 at New York. They defeated the Yankees 3–0, including 6.0 scoreless innings pitched by Keuchel and home runs by Colby Rasmus and Carlos Gómez.

The Astros would subsequently play the AL Central champion Kansas City Royals. The Astros would split the first two games of the ALDS best-of-five series in Kansas City. The Astros won the first game at Minute Maid to take a 2–1 lead in the ALDS. In Game 4, after 7 innings, the Astros had a 6–2 lead. In the top half of the eighth inning, which took about 45 minutes to end, the Royals had taken a 7–6 lead with 5 consecutive singles and a notable error from SS Carlos Correa which tied the game as well as allowed the winning run to reach base. The Astros suffered a 9–6 loss and the ALDS was tied at 2–2. Then the series went back to Kansas City, where the Royals clinched the series in the fifth game, 7–2.

The Astros entered the 2016 season as the favorites to win the AL West after a promising 2015 season. After a bad start to their season, going just 7–17 in April, the Astros bounced back and went on to have a winning record in their next four months, including an 18–8 record in June. But after going 12–15 in September, the Astros were eliminated from playoff contention. They finished in third place in the American League West Division with a final record of 84–78.

The season was marked by the Astros 4–15 record against their in-state division rival (and eventual division winner) Texas Rangers. The Astros finished the 2016 season 11 games behind the Rangers.

In 2014, Sports Illustrated predicted the Astros would win the 2017 World Series through their strategic rebuilding process. As of June 9, 2017, the Astros were 41–16, which gave them a 13.5-game lead over the rest of their division and comfortable possession of the best record in the entire league. This was the best start in the Astros' 55-year history. The Astros entered the All-Star Break with an American League-best 60–29 record, a 16-game lead in the division, and one game shy of the best record in MLB, which had just barely slipped to the Dodgers right before the All-Star Break.

With Hurricane Harvey causing massive flooding throughout Houston and southeast Texas, the Astros' three-game series against the Texas Rangers for August 29–31, was relocated to Tropicana Field (home of the Tampa Bay Rays), in St. Petersburg, Florida. As the area recovered from the hurricane, many residents rallied around the Astros, who adopted the mantra "Houston Strong". They wore a patch on their jerseys with the mantra for the remainder of the season.

At the August 31 waiver-trade deadline GM Jeff Luhnow acquired veteran starting pitcher and Cy Young Award winner Justin Verlander to bolster the starting rotation. Verlander won each of his 5 regular season starts with the Astros, yielding only 4 runs over this stretch. He carried his success into the playoffs, posting a record of 4–1 in his 6 starts, and throwing a complete game in Game 2 of the ALCS. Verlander was named the 2017 ALCS MVP.

The Astros clinched their first division title as a member of the American League West division, and first division title overall since 2001. They also became the first team in Major League history to win three different divisions: National League West in 1980 and 1986, National League Central from 1997 to 1999 and 2001, and American League West in 2017. On September 29, the Astros won their 100th game of the season, the second time the Astros finished a season with over 100 wins, the first being in 1998. They finished 101–61, with a 21-game lead in the division, and faced the Red Sox in the first round of the AL playoffs. The Astros defeated the Red Sox three games to one, and advanced to the American League Championship Series against the New York Yankees. The Astros won the ALCS four games to three, and advanced to the World Series to play against the Los Angeles Dodgers. The Astros defeated the Dodgers in the deciding seventh game of the World Series, winning the first championship in franchise history.

The victory was especially meaningful for the Houston area, which was rebuilding after Hurricane Harvey. The city of Houston celebrated the team's accomplishment with a parade on the afternoon of November 3, 2017. Houston police chief Art Acevedo estimated at least 750,000 people attended the parade.

On November 16, 2017, Jose Altuve was named the American League Most Valuable Player, capping off a season in which he accumulated 200 hits for the fourth consecutive season, led the majors with a .346 BA, and was the unquestioned clubhouse leader of the World Series champions.

On September 26, 2018, the Astros' second consecutive AL West division championship was clinched with a victory by the Seattle Mariners over the Oakland A's. For the third time in franchise history, and second consecutive season, the team won over 100 games; they finished the regular season 103–59 (a new franchise record) by sweeping a double-header against the Baltimore Orioles on September 29, 2018. The Astros swept the Cleveland Indians in the ALDS to advance to the ALCS to face the league-leading Boston Red Sox (who finished the season 108–54.) After a 7–2 victory in Game 1 of the ALCS, the Astros dropped the next four games, and Boston advanced to the World Series.

In the offseason, the Astros signed veteran outfielder Michael Brantley, and catcher Robinson Chirinos. At the trade deadline on July 31, 2019, Houston acquired another veteran starting pitcher and Cy Young award winner Zack Greinke to bolster the starting rotation. On September 22, the Astros clinched their third consecutive AL West division title. They finished the season with a record of 107–55, the best in franchise history, and the best record in MLB. They became the first team since the 2002–2004 New York Yankees to have 3 consecutive 100-win seasons. They also became the first team in MLB history to have three consecutive 100-loss seasons and three consecutive 100-win seasons in the same decade.

Entering the playoffs as the top-seeded team in both leagues, they defeated the AL Wild Card winner Tampa Bay Rays in five games in the ALDS, advancing to the ALCS for the third year in a row to face the New York Yankees. In Game 6 at Minute Maid Park, Jose Altuve hit a walk-off home run to win the pennant and send the team to its third World Series appearance. However, they lost the 2019 World Series to the Washington Nationals in seven games, taking three games in Washington but losing all four of their games at home.

On November 12, 2019, Ken Rosenthal and Evan Drellich wrote an article in The Athletic detailing allegations that the Astros had used cameras to engage in potentially illicit sign stealing against opponents, relying on allegations from former Astros pitcher Mike Fiers as a public source and other allegations from unnamed sources. The Astros were alleged to have used scouts watching catchers' signs in real time behind the dugout at Minute Maid Park to crack the signs and banging a trash can loudly to indicate what kind of pitch was coming. The scandal rippled through the baseball world as videos that appeared to clearly show the scheme were published. Further allegations regarding other means of relaying signs, such as whistling, surfaced in subsequent weeks. MLB and Commissioner Rob Manfred announced a sweeping investigation into the allegations.

On January 13, 2020, MLB announced that its investigation found that the Astros did use cameras and video monitors to steal signs of opposing catchers and signal to hitters throughout the 2017 regular season and postseason, and at least part of the 2018 season. The investigation found no evidence of sign stealing in their pennant-winning 2019 season. The report said that Alex Cora, then the Astros bench coach, Carlos Beltrán, and other unnamed players were involved in developing the scheme. It said Hinch "neither devised the banging scheme nor participated in it," but did not stop it or tell Cora he disapproved of it.

Manfred announced that manager A. J. Hinch and general manager Jeff Luhnow were suspended for one year, the team would be fined $5 million (the maximum allowed under MLB rules), and the team would lose its top two draft picks in both the 2020 and 2021 MLB Drafts. About an hour after MLB's announcement, Astros owner Jim Crane announced he had terminated both Hinch and Luhnow, saying he was unaware of the scheme and "extraordinarily troubled and upset", and concluded, "We need to move forward with a clean slate. [We] will not have this happen again on my watch." In a statement, Luhnow denied knowledge of the scheme. Hinch issued a statement saying, "While the evidence consistently showed I didn't endorse or participate in the sign stealing practices, I failed to stop them and I am deeply sorry."

The scandal had repercussions around baseball. Cora was implicated in the report but Manfred withheld a decision on his punishment until the completion of a separate investigation into electronic sign stealing in 2018, when Cora was manager of the Red Sox. However, the report led the Red Sox to dismiss Cora two days after it was published, and the Mets did the same with Beltran, who had been hired as manager shortly before the original story.

On January 29, 2020, the Astros announced they hired Dusty Baker as their new manager to replace Hinch. James Click was hired to replace Lunhow as general manager on February 2.

Expectations for a full 2020 season were dashed by the COVID-19 pandemic, which forced Major League Baseball to play a 60-game season that would take place from July to September with no fans in attendance (which was later changed for the NLCS and World Series). The Astros were hampered by injuries to players such as Justin Verlander, Yordan Alvarez, and Roberto Osuna, who each suffered season-ending injuries. As such, the Astros had to rely a plethora of young arms such as Cristian Javier to go alongside veterans in Lance McCullers Jr. and Zack Greinke to accompany an offense that had just one .300 batter in Michael Brantley. The Astros went 29–31, but finished second place in the AL West to qualify for the postseason as part of the decision by MLB to have eight postseason teams in each league for 2020 to accompany a shortened season. The Astros defeated two division champions in the Minnesota Twins and Oakland Athletics to become the first team since the 1998–2001 New York Yankees to advance to the American League Championship Series four times in a row, as well as the first team with a losing regular season record to win a postseason series. In the ALCS, the Astros lost to the Tampa Bay Rays despite forcing a Game 7 after losing the first three games.

The 2021 season was the first to be played with fans in the stands for the regular season since the scandal broke. Rabid opposition for a number of fanbases went hand in hand with the challenge of replacing departed players George Springer and Josh Reddick. By the time of the break for the 2021 MLB All-Star Game, the Astros were 55–36 and contending for a top spot in the postseason, complete with four All-Star selections in Jose Altuve, Carlos Correa, Michael Brantley, and Ryan Pressly. On September 30, the Astros clinched their fourth AL West title in the span of five seasons (which was the first time they had won four division titles in five seasons since the 1998–2001 teams); the six playoff appearances in seven seasons is the best span in franchise history. Yuli Gurriel became the second Astro to win the batting title, doing so at the age of 37 with a batting average of .319. The Astros beat the Chicago White Sox in the American League Division Series to advance to their fifth consecutive ALCS, a feat matched by only two teams in LCS history and the first since the Atlanta Braves of the 1990s (having made all eight contested NLCS from 1991 to 1999). Upon playing together in Game 3 of the 2021 American League Championship Series, Altuve, Correa, Gurriel, and Bregman set a new record for most games played together by four teammates at any position in MLB history, with that game being the 64th between the core four. On October 22, the Astros prevailed 5–0 in Game 6 over the Boston Red Sox to win their third pennant in the last five seasons. They went on to lose the 2021 World Series to the Atlanta Braves in six games.

The 2022 season opened without Carlos Correa at shortstop for the first time since 2016 as he left for the Minnesota Twins in free agency. Rookie shortstop Jeremy Peña made the Opening Day start and manned the position for the entire season. The Astros clinched the division on September 19, their second consecutive division title and their fifth in six seasons. Justin Verlander had a resurgent and historic season, leading the league with a 1.75 ERA en route to his third career Cy Young Award. Upon entering the postseason, the Astros swept the Mariners in three tightly contested ALDS games to advance to their American League record sixth consecutive ALCS. The Astros swept the Yankees to advance to the World Series for the second year in a row and fourth in six seasons. On November 2, 2022, in Game 4 of the 2022 World Series against the Philadelphia Phillies at the Citizens Bank Park, the Astros became the first team to throw a combined no-hitter in postseason history, and the second team to throw a no-hitter in World Series history after Don Larsen's perfect game with the New York Yankees in 1956. The Astros went on to defeat the Phillies in six games, earning their second World Series title. Jeremy Peña won the Series MVP Award; the first rookie position player in MLB history to do so, and the first rookie shortstop in history to hit a home run in the World Series. The Astros became the first team to have a winning percentage of .622 (or better) in a six-season span (2017–2022) with multiple World Series titles since the 1953-1958 New York Yankees, and they became the sixth team since 1960 to win the World Series after losing it the previous year.

During the 2022-23 offseason, Baker's contract was renewed for another year, while Click parted ways with the team following a breakdown of contractual negotiations. In February 2023, Dana Brown was hired as the new general manager for the Astros.

The 2023 season began inauspiciously with the Astros losing their first Opening Day game since 2012 in a 3–2 loss to the Chicago White Sox. This snapped a streak of 10-straight wins on Opening Day for the club, a modern-day record. It was also the first season since 2017 not to feature Yuli Gurriel at first base, who signed a minor league contract with the Miami Marlins, and instead was replaced by José Abreu, who the Astros had signed to a 3-year contract during the offseason. Entering the All-Star break, the Astros had a 50–41 record while sending Yordan Álvarez, Kyle Tucker, and Framber Valdez to the Midsummer Classic. The American League, managed by Dusty Baker, lost for the first time since 2012. After losing him to free agency in the offseason, the Astros reacquired Justin Verlander from the Mets at the trade deadline to bolster their rotation. After playing well in July and August, the Astros slumped in September, battling with the Mariners and the Rangers for the division all the way until the final game of the season. The Astros and Rangers finished tied at 90–72; however, the Astros won the division by virtue of their 9–4 season record against Texas. The Astros beat the Minnesota Twins in the ALDS to advance to their American League record seventh consecutive ALCS. Ultimately, the Astros fell in seven games to the Rangers, a series in which the away team won every game, reminiscent of the Astros defeat in the 2019 World Series.

On October 25, 2023, Baker announced his retirement. On November 13, 2023, Joe Espada was named the 25th manager in Astros history.

The Astros began the 2024 season in dreadful fashion by losing on Opening Day to the New York Yankees 5–4. They would be swept in four games on Opening Weekend.

Pitcher Ronel Blanco threw the first no-hitter of the 2024 season against the Toronto Blue Jays on April 1, 2024, as the Astros defeated Toronto 10–0. Blanco, making just his eighth career start after making the roster just a few days before, struck out seven and walked two to complete the seventeenth no-hitter in franchise history and the fourth at Minute Maid Park. First-year manager Joe Espada also made history that night, becoming the first manager in MLB history to earn their first managerial win via a no-hitter.

On May 13, 2024, in a game between the Astros and the Oakland Athletics, Jenny Cavnar and Julia Morales became the first two women to do the play-by-play on television for the same Major League Baseball game.

On July 29, 2024 Yusei Kikuchi became the first Japanese-born player to pitch for the Astros after being traded to Houston by the Toronto Blue Jays in exchange for prospects Joey Loperfido, Will Wagner and Jake Bloss. He made his debut with the Astros on August 2 against the Tampa Bay Rays, in which he tied a franchise record of eight consecutive strikeouts, previously accomplished by Don Wilson (1968), Jim Deshaies (1986) and Justin Verlander (2022). His 11 total strikeouts gave him the most in an Astros debut since Gerrit Cole in 2018. The Astros went on to win his nine first starts, a franchise record and the longest streak in the majors since John Burkett with the 2002 Boston Red Sox.

Outfielder Yordan Alvarez smacked three home runs on August 28, 2024, in a 10–0 victory over the Philadelphia Phillies, the third three-homer game of his career. He tied Hall of Famer Jeff Bagwell for the most three-homer games in Astros history.

On September 13, 2024, the Astros secured the 5,000th win in franchise history by defeating the Los Angeles Angels, 5–3, at Angel Stadium. The Astros became the second expansion team to reach 5,000 wins, following the Angels who reached the mark earlier in the season.

On September 24, 2024, the Astros clinched the AL West division title for the fourth straight year with a 4–3 victory over the Mariners, becoming the first team to win that division four seasons in a row since the Oakland Athletics won the division title from 1971 to 1975. It is their seventh division title in eight years. The Astros won the 2024 division title despite beginning the season 7–19, at one point trailing the Mariners by 10 games in the AL West, becoming the first team in the expansion era to begin the season with that record and still make the playoffs.