| Date | R | Home v Away | - | |
|---|---|---|---|---|
| 12/14 15:05 | - | Loughborough Lightning Women v Harlequins Women | L | 22-40 |
| 11/10 15:00 | - | Exeter Chiefs Women v Loughborough Lightning Women | L |
|
| 10/13 11:45 | - | Ealing Trailfinders Women v Loughborough Lightning Women | L | 64-33 |
| 06/02 14:00 | - | Loughborough Lightning Women v Saracens Women | L | 24-33 |
| 05/25 11:30 | - | Trailfinders Women v Loughborough Lightning Women | W | 18-19 |
| 05/12 13:45 | - | Loughborough Lightning Women v Gloucester Hartpury Women | L | 26-61 |
| 03/03 14:30 | - | Loughborough Lightning Women v Sale Sharks Women | W | 38-15 |
| 02/23 19:45 | - | Bristol Bears Women v Loughborough Lightning Women | L | 33-17 |
| 12/03 17:30 | - | Leicester Tigers Women v Loughborough Lightning Women | W | 12-24 |