| Date | R | Home v Away | - | |
|---|---|---|---|---|
| 01/30 17:00 | 4 | [5] Santos Laguna U23 v Puebla U23 [14] | D | 1-1 |
| 01/27 15:00 | 3 | Leon U23 v Santos Laguna U23 | W | 0-4 |
| 01/21 17:00 | 2 | [14] Santos Laguna U23 v Monterrey U23 [6] | W | 2-1 |
| 01/13 15:00 | 1 | Chivas Guadalajara U23 v Santos Laguna U23 | L | 3-2 |
| 11/18 15:00 | 3 | [2] Chivas Guadalajara U23 v Santos Laguna U23 [7] | L | 3-1 |
| 11/15 17:00 | 3 | [7] Santos Laguna U23 v Chivas Guadalajara U23 [2] | L | 2-4 |
| 11/11 15:00 | 17 | [18] Atletico San Luis U23 v Santos Laguna U23 [8] | D | 2-2 |
| 11/05 17:00 | 16 | [9] Santos Laguna U23 v Toluca U23 [15] | W | 2-1 |
| 11/01 16:00 | 15 | [9] Mazatlan FC U23 v Santos Laguna U23 [7] | L | 2-1 |
| 10/29 17:00 | 14 | [7] Santos Laguna U23 v Juarez FC U23 [8] | D | 0-0 |
| 10/21 15:00 | 13 | [7] Club America U23 v Santos Laguna U23 [9] | L | 3-2 |
| 10/14 15:00 | 4 | [14] Cruz Azul U23 v Santos Laguna U23 [9] | L | 4-1 |
| 10/08 15:00 | 12 | Santos Laguna U23 v Leon U23 | D | 0-0 |
| 10/04 17:00 | 11 | Santos Laguna U23 v Tijuana U23 | W | 5-0 |
| 09/30 15:00 | 10 | Monterrey U23 v Santos Laguna U23 | W | 1-2 |
| 09/24 17:00 | 9 | [11] Santos Laguna U23 v Necaxa U23 [7] | W | 5-0 |
| 09/18 15:30 | 8 | [2] Pachuca U23 v Santos Laguna U23 [9] | L | 2-0 |
| 09/02 17:00 | 7 | [9] Santos Laguna U23 v Unam Pumas U23 [8] | W | 2-0 |
| 08/30 15:00 | 5 | Tigres UANL U23 v Santos Laguna U23 | D | 1-1 |
| 08/26 17:00 | 6 | [8] Santos Laguna U23 v Chivas Guadalajara U23 [5] | L | 0-1 |
| 07/13 17:00 | 3 | Santos Laguna U23 v Atlas U23 | W | 2-1 |
| 07/07 15:00 | 2 | Puebla U23 v Santos Laguna U23 | L | 4-0 |
| 07/02 17:00 | 1 | Santos Laguna U23 v Queretaro U23 | W | 4-3 |