Head to Head
| Mexico Liga MX | 2016/02/06 23:00 | Club America v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2015/08/15 02:30 | Santos Laguna v Club America | L | 0-2 |
| Mexico Liga MX | 2015/03/14 23:00 | Club America v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2014/09/27 02:30 | Santos Laguna v Club America | L | 1-4 |
| Mexico Liga MX | 2014/05/04 02:00 | Santos Laguna v Club America | W | 3-1 |
| Mexico Liga MX | 2014/05/01 01:00 | Club America v Santos Laguna | L | 5-3 |
Home History
| Mexico Liga MX | 2016/03/12 03:30 | Santos Laguna v Pachuca | W | 3-2 |
| Mexico Liga MX | 2016/03/06 02:30 | Atlas v Santos Laguna | W | 1-2 |
| CONCACAF Champions Cup | 2016/03/02 03:00 | Santos Laguna v LA Galaxy | W | 4-0 |
| Mexico Liga MX | 2016/02/28 01:00 | Santos Laguna v Puebla | D | 1-1 |
| CONCACAF Champions Cup | 2016/02/25 03:00 | LA Galaxy v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2016/02/21 18:00 | Unam Pumas v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2016/02/13 03:30 | Santos Laguna v Monterrey | L | 1-2 |
| Mexico Liga MX | 2016/02/06 23:00 | Club America v Santos Laguna | L | 2-0 |
Away History
| Mexico Liga MX | 2016/03/14 01:30 | Chivas Guadalajara v Club America | W | 1-2 |
| Mexico Liga MX | 2016/03/05 23:00 | Club America v Mazatlan FC | W | 4-1 |
| CONCACAF Champions Cup | 2016/03/03 01:00 | Club America v Seattle Sounders | W | 3-1 |
| Mexico Liga MX | 2016/02/28 01:00 | Tigres UANL v Club America | L | 4-1 |
| CONCACAF Champions Cup | 2016/02/24 03:00 | Seattle Sounders v Club America | D | 2-2 |
| Mexico Liga MX | 2016/02/20 23:00 | Club America v Cruz Azul | D | 3-3 |
| Mexico Liga MX | 2016/02/13 01:30 | Veracruz v Club America | D | 1-1 |
| Mexico Liga MX | 2016/02/06 23:00 | Club America v Santos Laguna | W | 2-0 |