Southern Illinois 45-21 Western Illinois 2019-11-16 19:00
Stadium: Hanson Field Round: 1
Home Manager: Jared Elliott Away Manager: Nick Hill
Head to Head
| NCAAF FCS | 2018/11/03 18:00 | Western Illinois v SO Illinois | L | 34-31 |
| NCAAF | 2017/11/18 19:00 | Western Illinois v SO Illinois | L | 28-14 |
Home History
| NCAAF | 2019/11/09 20:00 | Missouri St v SO Illinois | W | 14-37 |
| NCAAF | 2019/11/02 17:00 | SO Illinois v Indiana State | W | 23-14 |
| NCAAF | 2019/10/26 21:00 | SO Illinois v South Dakota | W | 48-28 |
| NCAAF | 2019/10/19 19:00 | Youngstown State v SO Illinois | W | 10-35 |
| NCAAF | 2019/10/12 23:00 | Illinois State v SO Illinois | L | 21-7 |
| NCAAF | 2019/10/05 19:00 | SO Illinois v South Dakota State | L | 10-28 |
| NCAAF | 2019/09/21 23:00 | SO Illinois v Arkansas State | L | 28-41 |
| NCAAF | 2019/09/14 23:00 | Tennessee Martin v SO Illinois | W | 14-28 |
Away History
| NCAAF | 2019/11/09 20:30 | Western Illinois v North Dakota State | L | 21-57 |
| NCAAF | 2019/11/02 18:00 | South Dakota v Western Illinois | W | 34-38 |
| NCAAF | 2019/10/26 18:00 | Western Illinois v Youngstown State | L | 14-59 |
| NCAAF | 2019/10/19 18:00 | Illinois State v Western Illinois | L | 28-14 |
| NCAAF | 2019/10/12 17:00 | Western Illinois v Indiana State | L | 10-20 |
| NCAAF | 2019/10/05 20:00 | Missouri St v Western Illinois | L | 37-31 |
| NCAAF | 2019/09/21 20:00 | Tennessee Tech v Western Illinois | L | 38-24 |
| NCAAF | 2019/09/14 20:00 | Montana State v Western Illinois | L | 23-14 |