[3] Roger Federer 6-4,7-6 John Isner [20] 2019-09-22 14:45
Stadium: Palexpo Round: 44 Ground: Hardcourt indoor
Head to Head
| ATP Miami | 2019/03/31 17:00 | John Isner v Roger Federer | 1-6,4-6 |
| Laver Cup | 2018/09/23 19:00 | Roger Federer v John Isner | 6-7,7-6,10-7 |
| Laver Cup | 2018/09/23 18:30 | Roger Federer v John Isner | 6-7,7-6,1-0 |
| US Open | 2015/09/08 01:00 | John Isner v Roger Federer | 6-7,6-7,5-7 |
Home History
| Laver Cup | 2019/09/21 13:00 | Roger Federer v Nick Kyrgios | 6-7,7-5,10-7 |
| US Open | 2019/09/04 00:15 | Roger Federer v Grigor Dimitrov | 6-3,4-6,6-3,4-6,2-6 |
| US Open | 2019/09/01 16:00 | Roger Federer v David Goffin | 6-2,6-2,6-0 |
| US Open | 2019/08/30 16:00 | Roger Federer v Daniel Evans | 6-2,6-2,6-1 |
| US Open | 2019/08/28 17:25 | Roger Federer v Damir Dzumhur | 3-6,6-2,6-3,6-4 |
| US Open | 2019/08/27 01:00 | Roger Federer v Sumit Nagal | 4-6,6-1,6-2,6-4 |
| ATP Cincinnati | 2019/08/15 19:30 | Roger Federer v Andrey Rublev | 3-6,4-6 |
| ATP Cincinnati | 2019/08/13 23:00 | Roger Federer v Juan Ignacio Londero | 6-3,6-4 |
Away History
| Laver Cup | 2019/09/21 11:00 | Alexander Zverev v John Isner | 7-6,4-6,1-10 |
| US Open | 2019/08/31 18:40 | John Isner v Marin Cilic | 5-7,6-3,6-7,4-6 |
| US Open | 2019/08/29 18:30 | John Isner v Jan-Lennard Struff | 6-3,7-6,7-6 |
| US Open | 2019/08/27 17:25 | John Isner v Guillermo Garcia-Lopez | 6-3,6-4,6-4 |
| ATP Cincinnati | 2019/08/14 02:30 | Pablo Carreno Busta v John Isner | 6-4,6-7,7-6 |
| ATP Cincinnati | 2019/08/11 23:00 | Dusan Lajovic v John Isner | 6-7,6-1,5-7 |
| ATP Montreal | 2019/08/07 21:15 | Cristian Garin v John Isner | 6-3,6-4 |
| ATP Montreal | 2019/08/06 16:00 | Jordan Thompson v John Isner | 6-3,3-6,6-7 |