[3] Roger Federer 6-4,7-6 John Isner [20] 2019-09-22 14:45
Stadium: Palexpo Round: 44 Ground: Hardcourt indoor
Head to Head
| ATP Miami | 2019/03/31 17:00 | John Isner v Roger Federer | 1-6,4-6 |
| Laver Cup | 2018/09/23 19:00 | Roger Federer v John Isner | 6-7,7-6,10-7 |
| Laver Cup | 2018/09/23 18:30 | Roger Federer v John Isner | 6-7,7-6,1-0 |
| US Open | 2015/09/08 01:00 | John Isner v Roger Federer | 6-7,6-7,5-7 |