SE Missouri State 17-20 Southern Illinois 2020-10-30 23:00
Stadium: Saluki Stadium Round: 1
Head to Head
| NCAAF | 2019/08/29 23:30 | SO Illinois v SE Missouri St | W | 26-44 |
| NCAAF | 2018/09/15 23:00 | SE Missouri St v SO Illinois | W | 48-44 |
| NCAAF | 2017/09/16 23:00 | SE Missouri St v SO Illinois | L | 17-35 |
Home History
| NCAAF | 2019/11/30 19:00 | Illinois State v SE Missouri St | L | 24-6 |
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | W | 24-31 |
| NCAAF | 2019/11/16 18:00 | SE Missouri St v Eastern Illinois | W | 26-12 |
| NCAAF | 2019/11/09 19:00 | Eastern Kentucky v SE Missouri St | W | 31-38 |
| NCAAF | 2019/11/02 19:00 | SE Missouri St v Tennessee State | W | 32-13 |
| NCAAF | 2019/10/26 18:00 | Tennessee Martin v SE Missouri St | W | 10-17 |
| NCAAF | 2019/10/19 20:00 | SE Missouri St v Jacksonville State | W | 24-21 |
| NCAAF | 2019/10/12 19:00 | SE Missouri St v Austin Peay | L | 24-28 |
Away History
| NCAAF | 2019/11/23 20:00 | North Dakota State v SO Illinois | L | 21-7 |
| NCAAF | 2019/11/16 19:00 | SO Illinois v Western Illinois | W | 45-21 |
| NCAAF | 2019/11/09 20:00 | Missouri St v SO Illinois | W | 14-37 |
| NCAAF | 2019/11/02 17:00 | SO Illinois v Indiana State | W | 23-14 |
| NCAAF | 2019/10/26 21:00 | SO Illinois v South Dakota | W | 48-28 |
| NCAAF | 2019/10/19 19:00 | Youngstown State v SO Illinois | W | 10-35 |
| NCAAF | 2019/10/12 23:00 | Illinois State v SO Illinois | L | 21-7 |
| NCAAF | 2019/10/05 19:00 | SO Illinois v South Dakota State | L | 10-28 |