[6] London Irish 21-25 Harlequins [4] 2021-04-24 11:30
Stadium: London Round: 17
Referee: Matthew Carley Home Manager: Declan Kidney Away Manager: Paul Gustard
Head to Head
| Premiership Rugby | 2021/01/10 15:00 | Harlequins v London Irish | D | 27-27 |
| Premiership Rugby | 2020/09/09 18:45 | London Irish v Harlequins | L | 15-38 |
| Premiership Rugby | 2020/02/15 15:00 | Harlequins v London Irish | W | 15-29 |
| Premiership Rugby Cup | 2019/09/28 14:00 | London Irish v Harlequins | L | 18-21 |
| Premiership Rugby | 2018/04/07 14:00 | Harlequins v London Irish | W | 5-35 |
| Premiership Rugby | 2017/09/02 15:45 | London Irish v Harlequins | W | 39-29 |
| Premiership Rugby | 2016/05/01 14:00 | London Irish v Harlequins | L | 25-32 |
| European Rugby Challenge Cup | 2016/04/09 19:05 | Harlequins v London Irish | L | 38-30 |
Home History
| Premiership Rugby | 2021/04/16 18:45 | Northampton v London Irish | L | 44-26 |
| European Rugby Challenge Cup | 2021/04/09 19:00 | Bath v London Irish | L | 26-13 |
| European Rugby Challenge Cup | 2021/04/02 16:30 | London Irish v Cardiff Blues | W | 41-35 |
| Premiership Rugby | 2021/03/27 15:00 | London Irish v Bath | W | 36-33 |
| Premiership Rugby | 2021/03/21 15:00 | Sale Sharks v London Irish | L | 41-13 |
| Premiership Rugby | 2021/03/14 13:00 | London Irish v Worcester Warriors | W | 20-17 |
| Premiership Rugby | 2021/03/05 19:45 | Leicester v London Irish | L | 33-32 |
| Premiership Rugby | 2021/02/27 15:00 | Wasps v London Irish | W | 10-16 |
Away History
| Premiership Rugby | 2021/04/17 16:00 | Harlequins v Worcester Warriors | W | 50-26 |
| European Rugby Challenge Cup | 2021/04/04 19:00 | Harlequins v Ulster | L | 21-57 |
| Premiership Rugby | 2021/03/27 14:00 | Bristol v Harlequins | L | 35-33 |
| Premiership Rugby | 2021/03/20 14:00 | Harlequins v Gloucester | W | 59-24 |
| Premiership Rugby | 2021/03/13 12:30 | Exeter Chiefs v Harlequins | L | 21-20 |
| Premiership Rugby | 2021/03/07 15:00 | Harlequins v Northampton | W | 37-19 |
| Premiership Rugby | 2021/02/27 15:00 | Newcastle Falcons v Harlequins | L | 25-22 |
| Premiership Rugby | 2021/02/20 13:00 | Harlequins v Sale Sharks | W | 24-12 |