[6] London Irish 21-25 Harlequins [4] 2021-04-24 11:30
Stadium: London Round: 17
Referee: Matthew Carley Home Manager: Declan Kidney Away Manager: Paul Gustard
Head to Head
| Premiership Rugby | 2021/01/10 15:00 | Harlequins v London Irish | D | 27-27 |
| Premiership Rugby | 2020/09/09 18:45 | London Irish v Harlequins | L | 15-38 |
| Premiership Rugby | 2020/02/15 15:00 | Harlequins v London Irish | W | 15-29 |
| Premiership Rugby Cup | 2019/09/28 14:00 | London Irish v Harlequins | L | 18-21 |
| Premiership Rugby | 2018/04/07 14:00 | Harlequins v London Irish | W | 5-35 |
| Premiership Rugby | 2017/09/02 15:45 | London Irish v Harlequins | W | 39-29 |
| Premiership Rugby | 2016/05/01 14:00 | London Irish v Harlequins | L | 25-32 |
| European Rugby Challenge Cup | 2016/04/09 19:05 | Harlequins v London Irish | L | 38-30 |
| Premiership Rugby | 2015/12/05 15:00 | Harlequins v London Irish | L | 38-7 |
| Premiership Rugby | 2015/03/07 15:00 | Harlequins v London Irish | L | 26-20 |
| Premiership Rugby | 2014/09/06 15:30 | London Irish v Harlequins | L | 15-20 |