[85] Louisville 80-73 Duke [136] 2021-02-27 23:00
Stadium: Cameron Indoor Stadium
Home Manager: Mike Krzyzewski Away Manager: Chris Mack
Head to Head
| NCAAB | 2021/01/23 21:00 | Duke v Louisville | W | 65-70 |
| NCAAB | 2020/01/18 23:00 | Louisville v Duke | W | 79-73 |
| NCAAB | 2019/02/13 02:00 | Duke v Louisville | L | 71-69 |
| NCAAB | 2018/02/22 02:00 | Louisville v Duke | L | 56-82 |
| NCAAB | 2017/03/09 19:30 | Duke v Louisville | L | 81-77 |
| NCAAB | 2017/01/14 17:00 | Duke v Louisville | W | 69-78 |
| NCAAB | 2016/02/20 17:00 | Louisville v Duke | W | 71-64 |
| NCAAB | 2016/02/09 00:00 | Duke v Louisville | L | 72-65 |
Home History
| NCAAB | 2021/02/24 00:00 | Notre Dame v Louisville | W | 57-69 |
| NCAAB | 2021/02/20 23:00 | Louisville v North Carolina | L | 54-99 |
| NCAAB | 2021/02/01 19:00 | Georgia Tech v Louisville | W | 58-74 |
| NCAAB | 2021/01/28 02:00 | Louisville v Clemson | L | 50-54 |
| NCAAB | 2021/01/23 21:00 | Duke v Louisville | W | 65-70 |
| NCAAB | 2021/01/19 00:00 | Florida State v Louisville | L | 78-65 |
| NCAAB | 2021/01/17 01:00 | Louisville v Miami Florida | L | 72-78 |
| NCAAB | 2021/01/14 01:30 | Louisville v Wake Forest | W | 77-65 |
Away History
| NCAAB | 2021/02/23 00:00 | Syracuse v Duke | W | 71-85 |
| NCAAB | 2021/02/21 01:00 | Virginia v Duke | W | 65-66 |
| NCAAB | 2021/02/18 01:30 | Duke v Wake Forest | W | 84-60 |
| NCAAB | 2021/02/13 21:00 | Duke v NC State | W | 69-53 |
| NCAAB | 2021/02/09 21:30 | Notre Dame v Duke | L | 93-89 |
| NCAAB | 2021/02/06 23:00 | North Carolina v Duke | L | 91-87 |
| NCAAB | 2021/02/02 00:00 | Duke v Miami Florida | L | 75-77 |
| NCAAB | 2021/01/30 17:00 | Clemson v Duke | W | 53-79 |