[85] Louisville 80-73 Duke [136] 2021-02-27 23:00
Stadium: Cameron Indoor Stadium
Home Manager: Mike Krzyzewski Away Manager: Chris Mack
Head to Head
| NCAAB | 2021/01/23 21:00 | Duke v Louisville | W | 65-70 |
| NCAAB | 2020/01/18 23:00 | Louisville v Duke | W | 79-73 |
| NCAAB | 2019/02/13 02:00 | Duke v Louisville | L | 71-69 |
| NCAAB | 2018/02/22 02:00 | Louisville v Duke | L | 56-82 |
| NCAAB | 2017/03/09 19:30 | Duke v Louisville | L | 81-77 |
| NCAAB | 2017/01/14 17:00 | Duke v Louisville | W | 69-78 |
| NCAAB | 2016/02/20 17:00 | Louisville v Duke | W | 71-64 |
| NCAAB | 2016/02/09 00:00 | Duke v Louisville | L | 72-65 |
| NCAAB | 2015/01/17 17:00 | Louisville v Duke | L | 52-63 |