[42] West Virginia 6-42 Iowa State [14] 2020-12-05 20:30
Stadium: Jack Trice Stadium Round: 1
Head to Head
| NCAAF | 2019/10/12 20:00 | Iowa State v West Virginia | L | 38-14 |
| NCAAF | 2018/10/13 23:00 | West Virginia v Iowa State | L | 14-30 |
| NCAAF | 2017/11/04 19:30 | Iowa State v West Virginia | W | 16-20 |
| NCAAF | 2016/11/26 20:30 | West Virginia v Iowa State | W | 49-19 |
| NCAAF | 2015/11/28 17:00 | West Virginia v Iowa State | W | 30-6 |
| NCAAF | 2014/11/29 17:00 | Iowa State v West Virginia | W | 24-37 |
| NCAAF | 2012/11/23 12:00 | Iowa State v West Virginia | W | 24-31 |
Home History
| NCAAF | 2020/11/14 17:00 | TCU v West Virginia | W | 6-24 |
| NCAAF | 2020/11/07 17:00 | West Virginia v Texas | L | 13-17 |
| NCAAF | 2020/10/31 16:00 | Kansas State v West Virginia | W | 10-37 |
| NCAAF | 2020/10/24 21:30 | West Virginia v Texas Tech | L | 27-34 |
| NCAAF | 2020/10/17 16:00 | Kansas v West Virginia | W | 17-38 |
| NCAAF | 2020/10/03 16:00 | Baylor v West Virginia | W | 21-27 |
| NCAAF | 2020/09/26 19:30 | West Virginia v Oklahoma State | L | 13-27 |
| NCAAF | 2020/09/12 16:00 | Eastern Kentucky v West Virginia | W | 10-56 |
Away History
| NCAAF | 2020/11/27 17:00 | Iowa State v Texas | W | 23-20 |
| NCAAF | 2020/11/21 21:00 | Kansas State v Iowa State | W | 0-45 |
| NCAAF | 2020/11/08 00:00 | Baylor v Iowa State | W | 31-38 |
| NCAAF | 2020/10/31 16:00 | Iowa State v Kansas | W | 52-22 |
| NCAAF | 2020/10/24 19:30 | Iowa State v Oklahoma State | L | 21-24 |
| NCAAF | 2020/10/10 19:30 | Texas Tech v Iowa State | W | 15-31 |
| NCAAF | 2020/10/03 23:30 | Oklahoma v Iowa State | W | 30-37 |
| NCAAF | 2020/09/26 17:30 | Iowa State v TCU | W | 37-34 |