[42] West Virginia 6-42 Iowa State [14] 2020-12-05 20:30
Stadium: Jack Trice Stadium Round: 1
Head to Head
| NCAAF | 2019/10/12 20:00 | Iowa State v West Virginia | L | 38-14 |
| NCAAF | 2018/10/13 23:00 | West Virginia v Iowa State | L | 14-30 |
| NCAAF | 2017/11/04 19:30 | Iowa State v West Virginia | W | 16-20 |
| NCAAF | 2016/11/26 20:30 | West Virginia v Iowa State | W | 49-19 |
| NCAAF | 2015/11/28 17:00 | West Virginia v Iowa State | W | 30-6 |
| NCAAF | 2014/11/29 17:00 | Iowa State v West Virginia | W | 24-37 |
| NCAAF | 2012/11/23 12:00 | Iowa State v West Virginia | W | 24-31 |