[22] Northwestern 10-22 Ohio State [25] 2020-12-19 17:00
Stadium: Lucas Oil Stadium Round: 1
Head to Head
| NCAAF | 2019/10/19 00:30 | Ohio State v Northwestern | L | 52-3 |
| NCAAF | 2018/12/02 01:00 | Northwestern v Ohio State | L | 24-45 |
| NCAAF | 2016/10/29 19:30 | Northwestern v Ohio State | L | 20-24 |
| NCAAF | 2008/11/08 12:00 | Northwestern v Ohio State | L | 10-45 |
| NCAAF | 2007/09/22 12:00 | Ohio State v Northwestern | L | 58-7 |
| NCAAF | 2006/11/11 12:00 | Northwestern v Ohio State | L | 10-54 |
| NCAAF | 2005/11/12 12:00 | Ohio State v Northwestern | L | 48-7 |
| NCAAF | 2004/10/02 12:00 | Northwestern v Ohio State | W | 33-27 |
Home History
| NCAAF | 2020/12/12 17:00 | Illinois v Northwestern | W | 10-28 |
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | L | 20-29 |
| NCAAF | 2020/11/21 20:30 | Wisconsin v Northwestern | W | 7-17 |
| NCAAF | 2020/11/14 22:00 | Northwestern v Purdue | W | 27-20 |
| NCAAF | 2020/11/07 17:00 | Nebraska v Northwestern | W | 13-21 |
| NCAAF | 2020/10/31 19:30 | Northwestern v Iowa | W | 21-20 |
| NCAAF | 2020/10/24 23:30 | Maryland v Northwestern | W | 3-43 |
| NCAAF | 2019/11/30 17:00 | Northwestern v Illinois | W | 29-10 |
Away History
| NCAAF | 2020/12/05 17:00 | Ohio State v Michigan State | W | 52-12 |
| NCAAF | 2020/11/21 17:00 | Indiana v Ohio State | W | 35-42 |
| NCAAF | 2020/11/08 00:30 | Rutgers v Ohio State | W | 27-49 |
| NCAAF | 2020/10/31 23:30 | Ohio State v Penn State | W | 38-25 |
| NCAAF | 2020/10/24 16:00 | Nebraska v Ohio State | W | 17-52 |
| NCAAF | 2019/12/29 01:00 | Clemson v Ohio State | L | 29-23 |
| NCAAF | 2019/12/08 01:00 | Wisconsin v Ohio State | W | 21-34 |
| NCAAF | 2019/11/30 17:00 | Ohio State v Michigan | W | 56-27 |