[22] Northwestern 10-22 Ohio State [25] 2020-12-19 17:00
Stadium: Lucas Oil Stadium Round: 1
Head to Head
| NCAAF | 2019/10/19 00:30 | Ohio State v Northwestern | L | 52-3 |
| NCAAF | 2018/12/02 01:00 | Northwestern v Ohio State | L | 24-45 |
| NCAAF | 2016/10/29 19:30 | Northwestern v Ohio State | L | 20-24 |
| NCAAF | 2008/11/08 12:00 | Northwestern v Ohio State | L | 10-45 |
| NCAAF | 2007/09/22 12:00 | Ohio State v Northwestern | L | 58-7 |
| NCAAF | 2006/11/11 12:00 | Northwestern v Ohio State | L | 10-54 |
| NCAAF | 2005/11/12 12:00 | Ohio State v Northwestern | L | 48-7 |
| NCAAF | 2004/10/02 12:00 | Northwestern v Ohio State | W | 33-27 |
| NCAAF | 2003/09/27 12:00 | Ohio State v Northwestern | L | 20-0 |
| NCAAF | 2002/10/05 12:00 | Northwestern v Ohio State | L | 16-27 |
| NCAAF | 2001/10/06 12:00 | Ohio State v Northwestern | L | 38-20 |