[7] Santa Clara 0-4 Guimaraes [5] 2020-12-21 20:15
Stadium: Estadio de Sao Miguel Round: 10
Referee: Rui Manuel Gomes da Costa Home Manager: Daniel Ramos Away Manager: Joao Henriques
Head to Head
| Portugal Cup | 2020/12/13 14:00 | Guimaraes v Santa Clara | W | 0-1 |
| Portugal Primeira Liga | 2020/07/24 18:00 | Santa Clara v Guimaraes | D | 2-2 |
| Portugal Primeira Liga | 2020/01/18 15:30 | Guimaraes v Santa Clara | L | 1-0 |
| Portugal Primeira Liga | 2019/03/30 20:30 | Santa Clara v Guimaraes | W | 1-0 |
| Portugal Primeira Liga | 2018/11/11 15:00 | Guimaraes v Santa Clara | L | 2-0 |
| Europe Friendlies | 2018/07/22 10:00 | Guimaraes v Santa Clara | L | 3-2 |
Home History
| Portugal Cup | 2020/12/13 14:00 | Guimaraes v Santa Clara | W | 0-1 |
| Portugal Primeira Liga | 2020/12/06 15:00 | Nacional v Santa Clara | W | 1-3 |
| Portugal Primeira Liga | 2020/11/28 18:00 | Santa Clara v FC Porto | L | 0-1 |
| Portugal Cup | 2020/11/22 14:30 | Beira Mar v Santa Clara | W | 1-3 |
| Portugal Primeira Liga | 2020/11/07 15:00 | Tondela v Santa Clara | L | 2-0 |
| Portugal Primeira Liga | 2020/11/01 15:00 | Portimonense v Santa Clara | W | 1-2 |
| Portugal Primeira Liga | 2020/10/24 17:00 | Santa Clara v Sporting | L | 1-2 |
| Portugal Primeira Liga | 2020/10/18 14:00 | Pacos Ferreira v Santa Clara | L | 2-1 |
Away History
| Portugal League Cup | 2020/12/16 21:00 | Benfica v Guimaraes | L | 5-2 |
| Portugal Cup | 2020/12/13 14:00 | Guimaraes v Santa Clara | L | 0-1 |
| Portugal Primeira Liga | 2020/12/05 15:30 | Guimaraes v Portimonense | W | 1-0 |
| Portugal Primeira Liga | 2020/11/27 21:00 | Tondela v Guimaraes | W | 0-2 |
| Portugal Cup | 2020/11/21 16:30 | Arouca v Guimaraes | W | 6-7 |
| Portugal Primeira Liga | 2020/11/07 20:30 | Guimaraes v Sporting | L | 0-4 |
| Portugal Primeira Liga | 2020/11/01 17:30 | Gil Vicente v Guimaraes | W | 1-2 |
| Portugal Primeira Liga | 2020/10/25 20:00 | Guimaraes v Braga | L | 0-1 |