[7] Santa Clara 0-4 Guimaraes [5] 2020-12-21 20:15
Stadium: Estadio de Sao Miguel Round: 10
Referee: Rui Manuel Gomes da Costa Home Manager: Daniel Ramos Away Manager: Joao Henriques
Head to Head
| Portugal Cup | 2020/12/13 14:00 | Guimaraes v Santa Clara | W | 0-1 |
| Portugal Primeira Liga | 2020/07/24 18:00 | Santa Clara v Guimaraes | D | 2-2 |
| Portugal Primeira Liga | 2020/01/18 15:30 | Guimaraes v Santa Clara | L | 1-0 |
| Portugal Primeira Liga | 2019/03/30 20:30 | Santa Clara v Guimaraes | W | 1-0 |
| Portugal Primeira Liga | 2018/11/11 15:00 | Guimaraes v Santa Clara | L | 2-0 |
| Europe Friendlies | 2018/07/22 10:00 | Guimaraes v Santa Clara | L | 3-2 |