[6] Santos Laguna 2-0 Tigres UANL [5] 2021-01-18 01:06
Stadium: Estadio TSM Corona Round: 2
Referee: Fernando Guerrero Ramirez Home Manager: Guillermo Almada Away Manager: Ricardo Ferretti
Head to Head
| Mexico Liga MX | 2020/09/13 00:00 | Tigres UANL v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2020/02/17 00:45 | Santos Laguna v Tigres UANL | W | 2-1 |
| Mexico Liga MX | 2019/10/06 00:00 | Tigres UANL v Santos Laguna | L | 4-0 |
| CONCACAF Champions Cup | 2019/04/11 00:00 | Santos Laguna v Tigres UANL | W | 3-2 |
| CONCACAF Champions Cup | 2019/04/04 02:00 | Tigres UANL v Santos Laguna | L | 3-0 |
| Mexico Liga MX | 2019/02/03 01:00 | Tigres UANL v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2018/08/19 23:00 | Santos Laguna v Tigres UANL | W | 3-1 |
| Mexico Champion of Champions | 2018/07/16 01:00 | Tigres UANL v Santos Laguna | L | 4-0 |
Home History
| Mexico Liga MX | 2021/01/11 01:06 | Santos Laguna v Cruz Azul | W | 1-0 |
| Mexico Liga MX | 2020/11/22 01:00 | Santos Laguna v Pachuca | L | 0-3 |
| Mexico Liga MX | 2020/11/09 01:06 | Santos Laguna v Mazatlan FC | W | 4-0 |
| Mexico Liga MX | 2020/11/03 03:00 | Leon v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2020/10/26 01:06 | Santos Laguna v Atletico San Luis | W | 2-1 |
| Mexico Liga MX | 2020/10/19 00:06 | Santos Laguna v Pachuca | D | 1-1 |
| Mexico Liga MX | 2020/10/12 00:06 | Santos Laguna v Tijuana | W | 2-0 |
| Mexico Liga MX | 2020/10/03 00:30 | Puebla v Santos Laguna | W | 0-2 |
Away History
| Mexico Liga MX | 2021/01/10 01:00 | Tigres UANL v Leon | W | 2-0 |
| CONCACAF Champions Cup | 2020/12/23 03:00 | Tigres UANL v Los Angeles FC | W | 2-1 |
| CONCACAF Champions Cup | 2020/12/20 01:00 | Tigres UANL v CD Olimpia | W | 3-0 |
| CONCACAF Champions Cup | 2020/12/16 03:30 | Tigres UANL v New York City FC | W | 4-0 |
| Mexico Liga MX | 2020/11/30 00:30 | Cruz Azul v Tigres UANL | W | 0-1 |
| Mexico Liga MX | 2020/11/27 01:00 | Tigres UANL v Cruz Azul | L | 1-3 |
| Mexico Liga MX | 2020/11/23 01:00 | Tigres UANL v Toluca | W | 2-1 |
| Mexico Liga MX | 2020/11/08 01:00 | Tigres UANL v Atlas | D | 1-1 |