[5] Santos Laguna 3-1 Toluca [8] 2021-04-19 00:00
Stadium: Estadio TSM Corona Round: 15
Referee: Luis Enrique Santander Aguirre Home Manager: Guillermo Almada Away Manager: Hernan Cristante
Head to Head
| Mexico Liga MX | 2020/09/20 17:00 | Toluca v Santos Laguna | W | 1-2 |
| Mexico Liga MX | 2019/11/24 18:00 | Toluca v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2019/02/25 00:06 | Santos Laguna v Toluca | W | 4-0 |
| Mexico Liga MX | 2018/09/02 17:00 | Toluca v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2018/05/21 00:00 | Toluca v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/05/18 01:00 | Santos Laguna v Toluca | W | 2-1 |
| Mexico Liga MX | 2018/02/18 18:00 | Toluca v Santos Laguna | L | 2-0 |
| Mexico Cup | 2018/02/08 02:30 | Toluca v Santos Laguna | L | 2-0 |
Home History
| Mexico Liga MX | 2021/04/12 00:00 | Queretaro v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/04/04 22:00 | Chivas Guadalajara v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/03/22 01:06 | Santos Laguna v Leon | L | 1-2 |
| Mexico Liga MX | 2021/03/14 03:05 | Tijuana v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2021/03/08 01:06 | Santos Laguna v Necaxa | W | 3-1 |
| Mexico Liga MX | 2021/03/05 03:00 | Unam Pumas v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/03/01 01:06 | Santos Laguna v Juarez FC | W | 3-2 |
| Mexico Liga MX | 2021/02/19 03:00 | Atletico San Luis v Santos Laguna | L | 1-0 |
Away History
| Mexico Liga MX | 2021/04/11 17:00 | Toluca v Monterrey | L | 1-2 |
| Mexico Liga MX | 2021/04/05 02:05 | Leon v Toluca | L | 2-1 |
| Mexico Liga MX | 2021/03/21 18:00 | Toluca v Puebla | D | 4-4 |
| Mexico Liga MX | 2021/03/14 18:00 | Toluca v Pachuca | L | 0-2 |
| Mexico Liga MX | 2021/03/06 01:30 | Atletico San Luis v Toluca | D | 0-0 |
| Mexico Liga MX | 2021/03/03 01:00 | Tigres UANL v Toluca | W | 0-1 |
| Mexico Liga MX | 2021/02/27 23:00 | Toluca v Atlas | D | 0-0 |
| Mexico Liga MX | 2021/02/21 01:00 | Cruz Azul v Toluca | L | 3-2 |