Head to Head
| NFL Preseason | 2019/08/08 23:00 | IND Colts v BUF Bills | L | 16-24 |
| NFL | 2018/10/21 17:00 | BUF Bills v IND Colts | W | 5-37 |
| NFL | 2017/12/10 18:00 | IND Colts v BUF Bills | L | 7-13 |
| NFL Preseason | 2016/08/13 23:00 | BUF Bills v IND Colts | W | 18-19 |
| NFL | 2015/09/13 17:00 | BUF Bills v IND Colts | L | 27-14 |
Home History
| NFL | 2021/01/03 21:25 | JAX Jaguars v IND Colts | W | 14-28 |
| NFL | 2020/12/27 18:00 | IND Colts v PIT Steelers | L | 24-28 |
| NFL | 2020/12/20 18:00 | HOU Texans v IND Colts | W | 20-27 |
| NFL | 2020/12/13 21:05 | IND Colts v LV Raiders | W | 44-27 |
| NFL | 2020/12/06 18:00 | IND Colts v HOU Texans | W | 26-20 |
| NFL | 2020/11/29 18:00 | TEN Titans v IND Colts | L | 45-26 |
| NFL | 2020/11/22 21:25 | GB Packers v IND Colts | W | 31-34 |
| NFL | 2020/11/13 01:20 | IND Colts v TEN Titans | W | 34-17 |
Away History
| NFL | 2021/01/03 18:00 | MIA Dolphins v BUF Bills | W | 26-56 |
| NFL | 2020/12/29 01:15 | BUF Bills v NE Patriots | W | 38-9 |
| NFL | 2020/12/19 21:30 | BUF Bills v DEN Broncos | W | 48-19 |
| NFL | 2020/12/14 01:20 | PIT Steelers v BUF Bills | W | 15-26 |
| NFL | 2020/12/08 01:15 | BUF Bills v SF 49ers | W | 34-24 |
| NFL | 2020/11/29 18:00 | LA Chargers v BUF Bills | W | 17-27 |
| NFL | 2020/11/15 21:05 | BUF Bills v ARZ Cardinals | L | 30-32 |
| NFL | 2020/11/08 18:00 | SEA Seahawks v BUF Bills | W | 34-44 |