Louisville 50-54 Clemson 2021-01-28 02:00
Stadium: Littlejohn Coliseum
Home Manager: Brad Brownell Away Manager: Chris Mack
Head to Head
| NCAAB | 2020/02/15 21:00 | Louisville v Clemson | L | 62-77 |
| NCAAB | 2020/01/25 19:00 | Clemson v Louisville | W | 62-80 |
| NCAAB | 2019/02/16 17:00 | Clemson v Louisville | W | 55-56 |
| NCAAB | 2018/01/06 17:00 | Louisville v Clemson | L | 69-74 |
| NCAAB | 2017/01/20 02:00 | Clemson v Louisville | W | 60-92 |
| NCAAB | 2016/01/10 17:00 | Clemson v Louisville | L | 66-62 |
| NCAAB | 2015/01/08 02:00 | Louisville v Clemson | W | 58-52 |
| NIT | 2006/03/20 12:00 | Louisville v Clemson | W | 74-68 |
Home History
| NCAAB | 2021/01/23 21:00 | Duke v Louisville | W | 65-70 |
| NCAAB | 2021/01/19 00:00 | Florida State v Louisville | L | 78-65 |
| NCAAB | 2021/01/17 01:00 | Louisville v Miami Florida | L | 72-78 |
| NCAAB | 2021/01/14 01:30 | Louisville v Wake Forest | W | 77-65 |
| NCAAB | 2021/01/06 23:30 | Virginia Tech v Louisville | W | 71-73 |
| NCAAB | 2021/01/02 17:00 | Louisville v Boston College | W | 76-64 |
| NCAAB | 2020/12/26 18:00 | Kentucky v Louisville | W | 59-62 |
| NCAAB | 2020/12/23 00:00 | Louisville v Pittsburgh | W | 64-54 |
Away History
| NCAAB | 2021/01/23 20:00 | Clemson v Florida State | L | 61-80 |
| NCAAB | 2021/01/21 00:00 | Clemson v Georgia Tech | L | 65-83 |
| NCAAB | 2021/01/16 23:00 | Virginia v Clemson | L | 85-50 |
| NCAAB | 2021/01/06 00:00 | NC State v Clemson | W | 70-74 |
| NCAAB | 2021/01/02 19:00 | Clemson v Miami Florida | W | 66-65 |
| NCAAB | 2020/12/30 00:00 | Florida State v Clemson | W | 67-77 |
| NCAAB | 2020/12/21 17:00 | Morehead State v Clemson | W | 51-66 |
| NCAAB | 2020/12/15 23:30 | Clemson v Virginia Tech | L | 60-66 |