Louisville 50-54 Clemson 2021-01-28 02:00
Stadium: Littlejohn Coliseum
Home Manager: Brad Brownell Away Manager: Chris Mack
Head to Head
| NCAAB | 2020/02/15 21:00 | Louisville v Clemson | L | 62-77 |
| NCAAB | 2020/01/25 19:00 | Clemson v Louisville | W | 62-80 |
| NCAAB | 2019/02/16 17:00 | Clemson v Louisville | W | 55-56 |
| NCAAB | 2018/01/06 17:00 | Louisville v Clemson | L | 69-74 |
| NCAAB | 2017/01/20 02:00 | Clemson v Louisville | W | 60-92 |
| NCAAB | 2016/01/10 17:00 | Clemson v Louisville | L | 66-62 |
| NCAAB | 2015/01/08 02:00 | Louisville v Clemson | W | 58-52 |
| NIT | 2006/03/20 12:00 | Louisville v Clemson | W | 74-68 |