[11] BOS Bruins 5-1 BUF Sabres [31] 2021-04-22 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Bruce Cassidy
Head to Head
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | W | 2-0 |
| NHL | 2021/04/13 23:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2021/03/27 17:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2021/03/18 23:00 | BOS Bruins v BUF Sabres | W | 4-1 |
| NHL Pre-Season | 2020/03/09 12:42 | BOS Bruins v BUF Sabres | W | 3-2 |
| NHL | 2019/12/30 00:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2019/12/28 00:00 | BOS Bruins v BUF Sabres | W | 3-0 |
| NHL | 2019/11/22 00:00 | BUF Sabres v BOS Bruins | W | 2-3 |
Home History
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | W | 2-0 |
| NHL | 2021/04/18 16:00 | WAS Capitals v BOS Bruins | W | 3-6 |
| NHL | 2021/04/16 23:00 | NY Islanders v BOS Bruins | W | 0-3 |
| NHL | 2021/04/15 23:00 | NY Islanders v BOS Bruins | W | 1-4 |
| NHL | 2021/04/13 23:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2021/04/11 23:00 | WAS Capitals v BOS Bruins | L | 8-1 |
| NHL | 2021/04/10 18:00 | BOS Bruins v PHI Flyers | L | 2-3 |
| NHL | 2021/04/08 23:00 | BOS Bruins v WAS Capitals | W | 4-2 |
Away History
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | L | 2-0 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | W | 2-4 |
| NHL | 2021/04/17 19:00 | PIT Penguins v BUF Sabres | L | 3-2 |
| NHL | 2021/04/15 23:00 | BUF Sabres v WAS Capitals | W | 5-2 |
| NHL | 2021/04/13 23:00 | BUF Sabres v BOS Bruins | L | 2-3 |
| NHL | 2021/04/11 18:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2021/04/09 23:00 | WAS Capitals v BUF Sabres | L | 4-3 |
| NHL | 2021/04/08 23:00 | NJ Devils v BUF Sabres | L | 6-3 |