[11] BOS Bruins 5-1 BUF Sabres [31] 2021-04-22 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Bruce Cassidy
Head to Head
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | W | 2-0 |
| NHL | 2021/04/13 23:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2021/03/27 17:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2021/03/18 23:00 | BOS Bruins v BUF Sabres | W | 4-1 |
| NHL Pre-Season | 2020/03/09 12:42 | BOS Bruins v BUF Sabres | W | 3-2 |
| NHL | 2019/12/30 00:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2019/12/28 00:00 | BOS Bruins v BUF Sabres | W | 3-0 |
| NHL | 2019/11/22 00:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2019/01/06 00:00 | BUF Sabres v BOS Bruins | W | 1-2 |
| NHL | 2018/12/30 00:00 | BOS Bruins v BUF Sabres | W | 3-2 |
| NHL | 2018/12/16 22:00 | BUF Sabres v BOS Bruins | L | 4-2 |
| NHL | 2018/10/04 23:00 | BOS Bruins v BUF Sabres | W | 4-0 |
| NHL | 2018/02/25 22:00 | BOS Bruins v BUF Sabres | L | 1-4 |
| NHL | 2018/02/11 00:00 | BUF Sabres v BOS Bruins | L | 4-2 |
| NHL | 2017/12/20 00:30 | BOS Bruins v BUF Sabres | W | 3-0 |
| NHL | 2017/10/21 23:00 | BUF Sabres v BOS Bruins | L | 5-4 |
| NHL | 2016/12/31 18:00 | BUF Sabres v BOS Bruins | W | 1-3 |
| NHL | 2016/12/30 00:00 | BOS Bruins v BUF Sabres | W | 4-2 |
| NHL | 2016/12/03 18:00 | BOS Bruins v BUF Sabres | W | 2-1 |
| NHL | 2016/11/08 00:00 | BUF Sabres v BOS Bruins | W | 0-4 |