Head to Head
| Mexico Liga MX | 2017/04/24 00:00 | Santos Laguna v Club America | L | 2-1 |
| Mexico Cup | 2017/03/02 02:30 | Santos Laguna v Club America | L | 2-1 |
| Mexico Cup | 2017/01/19 02:30 | Club America v Santos Laguna | W | 3-2 |
| Mexico Liga MX | 2016/10/30 02:00 | Club America v Santos Laguna | W | 3-1 |
| CONCACAF Champions Cup | 2016/04/06 02:00 | Club America v Santos Laguna | W | 1-0 |
| CONCACAF Champions Cup | 2016/03/17 02:00 | Santos Laguna v Club America | D | 0-0 |
| Mexico Liga MX | 2016/02/06 23:00 | Club America v Santos Laguna | W | 2-0 |
| Mexico Liga MX | 2015/08/15 02:30 | Santos Laguna v Club America | W | 0-2 |
Home History
| Mexico Liga MX | 2017/05/07 02:00 | Club America v Pachuca | L | 2-3 |
| Mexico Liga MX | 2017/04/30 02:00 | Club America v Atlas | L | 1-2 |
| Mexico Liga MX | 2017/04/24 00:00 | Santos Laguna v Club America | L | 2-1 |
| Mexico Liga MX | 2017/04/16 02:00 | Club America v Queretaro | W | 1-0 |
| Mexico Liga MX | 2017/04/13 02:00 | Club America v Necaxa | W | 1-0 |
| Mexico Liga MX | 2017/04/08 02:00 | Tijuana v Club America | D | 0-0 |
| Mexico Liga MX | 2017/04/02 03:00 | Club America v Monterrey | W | 1-0 |
| Mexico Liga MX | 2017/03/19 18:00 | Unam Pumas v Club America | W | 2-3 |
Away History
| World Club Friendlies | 2017/07/02 22:00 | Chivas Guadalajara v Santos Laguna | W | 0-5 |
| Mexico Liga MX | 2017/05/14 02:00 | Toluca v Santos Laguna | W | 1-3 |
| Mexico Liga MX | 2017/05/11 02:30 | Santos Laguna v Toluca | L | 1-4 |
| Mexico Liga MX | 2017/05/07 23:00 | Santos Laguna v Toluca | D | 2-2 |
| Mexico Liga MX | 2017/04/29 22:00 | Jaguares de Chiapas FC v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2017/04/24 00:00 | Santos Laguna v Club America | W | 2-1 |
| Mexico Liga MX | 2017/04/16 00:00 | Atlas v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2017/04/13 00:30 | Santos Laguna v Monterrey | D | 2-2 |