[5] Stefanos Tsitsipas 6-3,6-2 John Isner [27] 2021-03-18 04:00
Stadium: Estadio Arena GNP Seguros Round: 26 Ground: Hardcourt outdoor
Head to Head
| ATP New York | 2020/08/25 21:30 | John Isner v Stefanos Tsitsipas | 6-7,6-7 |
| ATP Beijing | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| Wimbledon | 2018/07/09 13:40 | John Isner v Stefanos Tsitsipas | 6-4,7-6,7-6 |
| ATP Shanghai | 2017/10/11 12:20 | Stefanos Tsitsipas v John Isner | 6-7,6-7 |
Home History
| ATP Acapulco | 2021/03/17 02:40 | Stefanos Tsitsipas v Benoit Paire | 6-3,6-1 |
| ATP Marseille | 2021/03/12 17:00 | Pierre-Hugues Herbert v Stefanos Tsitsipas | 6-7,6-4,6-2 |
| ATP Marseille | 2021/03/11 17:55 | Lucas Pouille v Stefanos Tsitsipas | 2-6,3-6 |
| ATP Rotterdam | 2021/03/06 14:10 | Andrey Rublev v Stefanos Tsitsipas | 6-3,7-6 |
| ATP Rotterdam | 2021/03/05 12:00 | Karen Khachanov v Stefanos Tsitsipas | 6-4,3-6,5-7 |
| ATP Rotterdam | 2021/03/04 14:00 | Hubert Hurkacz v Stefanos Tsitsipas | 4-6,6-4,5-7 |
| ATP Rotterdam | 2021/03/02 18:30 | Egor Gerasimov v Stefanos Tsitsipas | 6-7,5-7 |
| Australian Open | 2021/02/19 08:30 | Daniil Medvedev v Stefanos Tsitsipas | 6-4,6-2,7-5 |
Away History
| ATP Acapulco | 2021/03/16 01:20 | John Isner v Salvatore Caruso | 6-4,6-3 |
| ATP Delray Beach | 2021/01/11 23:00 | Sebastian Korda v John Isner | 6-3,4-6,6-3 |
| ATP Delray Beach | 2021/01/10 01:35 | Thiago Monteiro v John Isner | 4-6,6-7 |
| French Open | 2020/09/30 09:30 | Sebastian Korda v John Isner | 6-4,6-4,2-6,6-4 |
| French Open | 2020/09/27 11:30 | Elliot Benchetrit v John Isner | 4-6,1-6,3-6 |
| US Open | 2020/08/31 22:30 | Steve Johnson v John Isner | 6-7,6-3,6-7,6-3,7-6 |
| ATP New York | 2020/08/25 21:30 | John Isner v Stefanos Tsitsipas | 6-7,6-7 |
| ATP New York | 2020/08/24 17:05 | John Isner v John Millman | 4-6,7-6,7-6 |