[5] Stefanos Tsitsipas 6-3,6-2 John Isner [27] 2021-03-18 04:00
Stadium: Estadio Arena GNP Seguros Round: 26 Ground: Hardcourt outdoor
Head to Head
| ATP New York | 2020/08/25 21:30 | John Isner v Stefanos Tsitsipas | 6-7,6-7 |
| ATP Beijing | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| Wimbledon | 2018/07/09 13:40 | John Isner v Stefanos Tsitsipas | 6-4,7-6,7-6 |
| ATP Shanghai | 2017/10/11 12:20 | Stefanos Tsitsipas v John Isner | 6-7,6-7 |